Key result
Entire pulmonary venous component isolation for persistent atrial fibrillation reduced atrial tachyarrhythmia recurrence at 1 year compared with PVI alone (33% vs 61%; OR 0.32; 95% CI 0.18-0.56).
Why the study?
Outcomes of pulmonary vein isolation for persistent AF are suboptimal, and the entire pulmonary venous component provides triggers and substrate that may serve as an alternative ablation target.
Does entire pulmonary venous component isolation reduce atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation compared to pulmonary vein isolation alone?
Observational (n=200)
Does entire pulmonary venous component isolation reduce atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation compared to pulmonary vein isolation alone?
Odds Ratio: 0.32 (95% CI 0.18–0.56)
Absolute Event Rate: 33% vs 61%
p-value: p=<.001
Entire pulmonary venous component isolation significantly reduces atrial tachyarrhythmia recurrence at 1 year compared to PVI alone in patients with persistent AF, without increasing procedural complications.
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May benefit persistent AF ablation patients; leaves open randomized confirmation before practice change.
Elbatran et al. (2019) conducted an observational in Persistent atrial fibrillation (n=200). Entire pulmonary venous component (PV-Comp) isolation vs. Pulmonary vein isolation (PVI) alone was evaluated on Atrial tachyarrhythmia (AF/atrial tachycardia) recurrence at 12 months (OR 0.32, 95% CI 0.18-0.56, p=<.001). Entire pulmonary venous component isolation for persistent atrial fibrillation reduced atrial tachyarrhythmia recurrence at 1 year compared with PVI alone (33% vs 61%; OR 0.32; 95% CI 0.18-0.56).
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