Key result
In Langendorff-perfused rabbit hearts, the spiral core of sustained monomorphic ventricular tachycardia is characterized by diminished V(m) and Ca(i) amplitudes (P<0.001) and persistent elevations.
Population
Langendorff-perfused rabbit hearts (n = 12)
Comparison
BAPTA-AM (a calcium chelator) vs Control (no BAPTA-AM)
Design
Preclinical
Authors
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Suggests calcium-targeted modulation in experimental VT; extends rabbit models but leaves open human translation.
p-value: p=<0.001
Endocardial spiral waves anchoring to anatomic discontinuities cause stable MVT in normal rabbit ventricles, supported by persistent V(m) and Ca(i) elevations at the core that can be prevented by calcium chelation.
Tang et al. (2008) studied Sustained monomorphic ventricular tachycardia (n=12). BAPTA-AM (calcium chelator) vs. Control was evaluated on Maximal V(m) and Ca(i) amplitudes at the spiral core relative to control (p=<0.001). In Langendorff-perfused rabbit hearts, the spiral core of sustained monomorphic ventricular tachycardia is characterized by diminished V(m) and Ca(i) amplitudes (P<0.001) and persistent elevations.
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