Population
Mouse neuroblastoma cells and mouse L cells
Comparison
Cell fusion using inactivated Sendai virus to… vs Parental neuroblastoma cells and parental L cells
Design
Preclinical
Follow-up
10-40 generations after fusion
Authors
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Hypothesis-generating for neuronal gene expression in hybrids; leaves open translation beyond this in vitro model.
The study demonstrates that genetic information for neuronal differentiation, specifically electrical excitability, can be functionally expressed in somatic cell hybrids of neuroblastoma and L cells.
Minna et al. (1971) studied this question.
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