Key result
Tetrodotoxin and scorpion venom reveal varying sensitivity in neuroblastoma hybrids, suggesting genetically distinct membrane excitability.
Population
Two hybrid cell lines resulting from the fusion of excitable human neuroblastoma cells with mouse fibroblasts
Design
Preclinical
Authors
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No immediate clinical implications; leaves open genetic dissection of excitability components in human neuronal hybrids.
The phenotype of membrane excitability appears to be composed of genetically distinct elements, as demonstrated by differing neurotoxin sensitivities in human neuroblastoma cell hybrids.
Giovanni et al. (1988) studied Neuroblastoma. Tetrodotoxin (TTX) and scorpion venom was evaluated on Presence of neurotoxin-responsive Na+ channels. Human neuroblastoma cell hybrids showed varying sensitivity to tetrodotoxin and scorpion venom, suggesting that the phenotype of membrane excitability is composed of genetically distinct elements.
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