Why the study?
Does recombinant growth hormone improve bone mineral density in adults with panhypopituitarism?
Population
6 adults with growth hormone deficiency and panhypopituitarism, plus a growth hormone deficient control group
Comparison
Recombinant growth hormone 0.04-0.1 U/kg/day for… vs Growth hormone deficient control group without…
Design
Cohort
Follow-up
12 to 18 months
Authors
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May support GH for BMD gains in panhypopituitarism; hypothesis-generating and requires RCTs before practice change.
Does recombinant growth hormone improve bone mineral density in adults with panhypopituitarism?
Recombinant growth hormone substitution significantly increases bone mineral density and improves body composition in adults with panhypopituitarism.
Degerblad et al. (1992) studied this question.
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