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July 1, 1998Radiographics

Simultaneous and correlated detection of endocardial and epicardial borders on short-axis MR images for the measurement of left ventricular mass.

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Why the study?

Does an automated segmentation approach on short-axis MR images accurately measure left ventricular mass compared to ex vivo measurement and manual assessment in Yucatan minipigs?

Population

9 Yucatan minipigs (test sample of 59 sections obtained during diastole)

Comparison

Automated segmentation approach using short-axis… vs Ex vivo mass measurement and interactive manual…

Design

Preclinical

Authors

PBP. BalzerAFAlain FurberCCChristine Cavaro‐Ménard

Discussion

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Overview

Supports automated LV mass quantification in animal models; leaves open translation to clinical cardiac MRI.

Key Points

  • The aim is to develop and validate a reproducible method for assessing left ventricular mass using MR imaging.
  • Utilized short-axis magnetic resonance imaging for mass measurement.
  • Implemented an integrated segmentation approach involving region growing and edge detection.
  • Measured mass in nine Yucatan minipigs comparing ex vivo and in vivo assessments.
  • Good correlation between actual mass and automatically assessed mass (SEE = 5 g).
  • Interobserver variability in manual mass assessment was similarly low (SEE = 4 g).
  • Technique allows precise delineation of left ventricular borders without needing to locate the ventricular cavity.

Structured PICO

Does an automated segmentation approach on short-axis MR images accurately measure left ventricular mass compared to ex vivo measurement and manual assessment in Yucatan minipigs?

P
Population
9 Yucatan minipigs (test sample of 59 sections obtained during diastole)
I
Intervention
Automated segmentation approach using short-axis MR imaging (region growing, edge detection, adaptive thresholding) for in vivo mass assessment
C
Comparator
Ex vivo mass measurement and interactive manual mass assessment by two trained observers
O
Outcome
Left ventricular mass measurement accuracy/correlationsurrogate

An automated segmentation approach for short-axis MR images provides accurate left ventricular mass measurements comparable to manual assessment and ex vivo measurements in a preclinical model.

Cite This Study

Balzer et al. (1998) studied this question.

synapsesocial.com/papers/6a74ab1e6a5eb4b8f5091e20https://doi.org/10.1148/radiographics.18.4.9672983
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