OP04.05: Time interval assessment of ventricular inflow patterns in normal singleton fetuses

To investigate the duration of biphasic inflow pattern in right and left ventricules of normal singleton fetuses. This cross-sectional study included 230 normal fetuses aged 18 to 38 week's gestation. The following time intervals were taken: from the peak of the E-wave, which formed by early ventricular diastole, to the peak of the A-wave, which formed by atrial contraction. These indices were measured both in right ventricule (Rt-EA) and left ventricule (Lt-EA) and also correlated with gestational age and fetal heart rate. Spearman's rank correlation coefficient and Wilcoxon rank sum test were used for statistical analysis. Regarding the correlation to the gestational age, Lt-EA showed significant positive correlation (r = 0.321, p <0.001). Significant correlation to the fetal heart rate were observed both in Rt- and Lt-EA (r = −0.504, p <0.001 and r = −0.654, p <0.001, respectively). In addition, Lt-EA showed significant prolongation compared to Rt-EA (p <0.001). This study firstly showed gestational changes of time interval of ventricular inflow pattern in uncomplicated fetuses. In addition, different evolution in right and left heart was suggested in fetal life. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.