Two years of oral l-arginine supplementation significantly improved endothelial function to control levels in patients with MELAS.
The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.
Koga et al. (Mon,) conducted a other in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke). oral l-arginine vs. controls was evaluated on endothelial function by flow-mediated vasodilation (FMD). Two years of oral l-arginine supplementation significantly improved endothelial function to control levels in patients with MELAS.