Key result
Two years of oral l-arginine supplementation significantly improved endothelial function to control levels in patients with MELAS.
Why the study?
Does oral l-arginine supplementation improve endothelial function in patients with MELAS?
Does oral l-arginine supplementation improve endothelial function in patients with MELAS?
Long-term oral l-arginine supplementation improves endothelial dysfunction in patients with MELAS, suggesting a potential therapeutic role for stroke-like episodes.
The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.
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Koga et al. (2006) studied MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke). oral l-arginine vs. controls was evaluated on endothelial function by flow-mediated vasodilation (FMD). Two years of oral l-arginine supplementation significantly improved endothelial function to control levels in patients with MELAS.
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