Key result
Stroke onset exhibited significant circadian variation with peaks in the morning (7-9 a.m.) and evening (7-9 p.m.) (p < 0.0001), as well as non-uniform circaseptan distribution (p < 0.016).
Cross-Sectional (n=869)
No
p-value: p=< 0.0001
Stroke occurrence exhibits significant circadian and circaseptan variations, with peaks in the morning and evening.
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May inform timing of acute stroke care; leaves open whether chronotherapy trials can reduce incidence.
Hosseininezhad et al. (2015) conducted a cross-sectional in stroke (n=869). Time of day and day of week was evaluated on Circadian and circaseptan variation of stroke onset (p=< 0.0001). Stroke onset exhibited significant circadian variation with peaks in the morning (7-9 a.m.) and evening (7-9 p.m.) (p < 0.0001), as well as non-uniform circaseptan distribution (p < 0.016).