Why the study?
Do imipramine and amitriptyline inhibit HERG potassium channels in CHO cells?
Population
CHO cells transiently transfected with HERG cDNA
Comparison
Imipramine and amitriptyline vs Control (absence of drug)
Design
Preclinical
Authors
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May explain TCA-related QT prolongation; leaves open clinical arrhythmia relevance pending human data.
Do imipramine and amitriptyline inhibit HERG potassium channels in CHO cells?
Imipramine and amitriptyline inhibit HERG potassium channels, providing a mechanistic explanation for QT prolongation and arrhythmia risk associated with TCA overdose.
Teschemacher et al. (1999) studied this question.
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