Population
Single guinea pig ventricular myocytes
Comparison
Imipramine (1, 5, and 10 mumol/L) vs Absence of imipramine
Design
Preclinical
Authors
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Hypothesis-generating for imipramine's antiarrhythmic effects in myocytes; leaves open clinical translation and safety in humans.
Imipramine exhibits antiarrhythmic properties by preferentially blocking rapidly activating K+ channels and delaying the activation of slowly activating K+ channels in ventricular myocytes.
Valenzuela et al. (1994) studied this question.
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