Key result
Imipramine reversibly inhibits neuronal M-type K+ current in rat sympathetic neurons with ~7 microM IC50.
Why the study?
The effects of the antidepressant imipramine on the neuronal M-type K+ current (IK(M)) were not fully characterized.
Population
Rat sympathetic neurons
Comparison
Imipramine exposure vs no exposure
Design
Preclinical electrophysiological study
Authors
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May alter sympathetic neuronal excitability; leaves open relevance to imipramine's clinical effects in humans.
Effect estimate: IC50 7 microM
Imipramine inhibits the M-type K+ current in rat sympathetic neurons via a voltage-independent mechanism, with the neutral form of the drug likely binding more efficiently.
Cuellar-Quintero et al. (2001) studied this question. Imipramine was evaluated on M-type K+ current (IK(M)) inhibition (IC50 7 microM). Imipramine reversibly inhibits the neuronal M-type K+ current in rat sympathetic neurons with an IC50 of 7 microM via a voltage-independent mechanism.
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