March 1, 1990Journal of Cardiovascular Pharmacology
Tonic and Frequency-Dependent Vmax Block Induced by Imipramine in Guinea Pig Ventricular Muscle Fibers
Why the study?
Does imipramine affect the maximum upstroke velocity (Vmax) of the action potential in isolated guinea pig papillary muscles?
Population
Isolated guinea pig papillary muscles
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May warrant conduction monitoring with imipramine; leaves open translation of guinea pig sodium channel effects to humans.
Structured PICO
Does imipramine affect the maximum upstroke velocity (Vmax) of the action potential in isolated guinea pig papillary muscles?
P
Population
Isolated guinea pig papillary muscles
I
Intervention
Imipramine (10(-7) to 5 X 10(-5) M)
O
Outcome
Maximum upstroke velocity (Vmax) of the action potentialsurrogate
Imipramine exhibits frequency- and voltage-dependent inhibition of fast sodium channels in guinea pig ventricular muscle, similar to class Ib antiarrhythmics.
Cite This Study
Delpón et al. (1990) studied this question.