January 1, 1997British Journal of PharmacologyOpen Access

Electrophysiological effects of CI‐980, a tubulin binding agent, on guinea‐pig papillary muscles

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Population

Right ventricular papillary muscles from guinea-pig hearts

Design

Preclinical

Authors

OPOnésima PérezUniversidad Complutense de Madrid CVCarmen ValenzuelaUniversity of Havana EDEva DelpónElectrophysiology

Discussion

Member takes

Implication

CI-980 shows dual antiarrhythmic effects in guinea-pig tissue; leaves open translation to in vivo models or clinical arrhythmias.

Structured PICO

Population

Right ventricular papillary muscles from guinea-pig hearts

Intervention

CI-980 (tubulin-binding agent) at concentrations ≥ 10(-6) M to 10(-5) M

Outcome

Transmembrane action potential characteristics including maximum upstroke velocity (Vmax), action potential duration (APD50, APD90), and effective refractory period (ERP)surrogate

CI-980 demonstrates class I and class III antiarrhythmic properties in guinea-pig ventricular tissue by inhibiting Vmax and prolonging action potential duration.

Cite This Study

Pérez et al. (1997) studied this question.

synapsesocial.com/papers/6a1a0e333f3ec013f0df6cc7 https://doi.org/10.1038/sj.bjp.0700878

View Full Paper

Ask AI

Bookmark

Electrophysiological effects of CI‐980, a tubulin binding agent, on guinea‐pig papillary muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological effects of CI‐980, a tubulin binding agent, on guinea‐pig papillary muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider