Key result
Hormone replacement therapy with L-thyroxine restored euthyroidism and markedly improved cardiac function, increasing left ventricular ejection fraction from 23% to 55% over 8 months.
Why the study?
Prolonged hypothyroidism is known to reduce myocardial contractility, but its direct role in the development of dilated cardiomyopathy with heart failure remains a matter of debate.
Does L-thyroxine and guideline-directed medical therapy improve cardiac function in a patient with dilated cardiomyopathy attributed to severe hypothyroidism?
Case Report (n=1)
Does L-thyroxine and guideline-directed medical therapy improve cardiac function in a patient with dilated cardiomyopathy attributed to severe hypothyroidism?
Absolute Event Rate: 55% vs 23%
Severe dilated cardiomyopathy can be a reversible consequence of profound hypothyroidism, highlighting the importance of routine thyroid function screening in new-onset heart failure.
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Supports thyroid screening in new HF; hypothesis-generating for reversible DCM, needs prospective trials.
Sani et al. (2025) conducted a case report in Dilated cardiomyopathy and hypothyroidism (n=1). L-thyroxine was evaluated on Left ventricular ejection fraction (LVEF). Hormone replacement therapy with L-thyroxine restored euthyroidism and markedly improved cardiac function, increasing left ventricular ejection fraction from 23% to 55% over 8 months.
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