January 1, 1983The Japanese Journal of PharmacologyOpen Access

Mechanism of antiarrhythmic action of a pyrrolizidine compound, SUN 1165.

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Population

Sinoatrial node (SAN) cells of rabbit, papillary muscle (PM) of guinea pig, and canine Purkinje fiber (PF)

Design

Preclinical

Authors

NINorio InomataKobe Asahi Hospital HKHiroaki KubotaTokai University TITakafumi IshiharaWaseda University

Discussion

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Implication

SUN 1165 adds to preclinical Class IB candidates; leaves open translation to clinical arrhythmia therapy.

Structured PICO

Population

Sinoatrial node (SAN) cells of rabbit, papillary muscle (PM) of guinea pig, and canine Purkinje fiber (PF)

Intervention

SUN 1165 (N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride)

Outcome

Electrophysiological effects including action potential duration (APD), effective refractory period (ERP), and maximum rate of rise of phase 0 depolarization (Vmax)surrogate

SUN 1165 is a novel compound that exhibits Class IB antiarrhythmic properties with quinidine-like effects in preclinical cellular models.

Cite This Study

Inomata et al. (1983) studied this question.

synapsesocial.com/papers/6a74eb9c80fadadbba0932f7 https://doi.org/10.1016/s0021-5198(19)64972-3

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Mechanism of antiarrhythmic action of a pyrrolizidine compound, SUN 1165.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of antiarrhythmic action of a pyrrolizidine compound, SUN 1165.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider