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December 1, 1991British Journal of PharmacologyOpen Access

Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea‐pig

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Authors

NINorio InomataKobe Asahi Hospital TITakafumi IshiharaWaseda University NANorio AkaikeYamamoto Hospital

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Implication

In vitro data on SUN 1165's IK.ACh effects; leaves open clinical translation for antiarrhythmic use.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Inomata et al. (1991) studied this question.

synapsesocial.com/papers/6a9100ba17bbbfe73e74539c https://doi.org/10.1111/j.1476-5381.1991.tb12541.x

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Anti-cholinergic effects of quinidine, disopyramide, and procainamide in isolated atrial myocytes: mediation by different molecular mechanisms.1989 · 66 citations
2Effect of SUN 1165, a New Potent Antiarrhythmic Agent, on the Kinetics of Rate-Dependent Block of Na Channels and Ventricular Conduction of Extrasystoles1988 · 42 citations
3Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes.1990 · 179 citations
4Acetylcholine activation of K+ channels in cell-free membrane of atrial cells1986 · 124 citations
5Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G <sub>k</sub>1987 · 438 citations