Population
Dissociated guinea-pig atrial myocytes
Design
Preclinical
Authors
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Differential anti-acetylcholine mechanisms among class I agents may influence vagal arrhythmia therapy; leaves open clinical translation from animal data.
Antiarrhythmic drugs exhibit different mechanisms of anti-acetylcholine effects, with pilsicainide and disopyramide mainly blocking muscarinic receptors, while flecainide and propafenone act as open channel blockers.
Inomata et al. (1993) studied this question.
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