Why the study?
Does SUN 1165 affect the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles similarly to other antiarrhythmic agents in preclinical models?
Population
Isolated guinea pig papillary muscles and anesthetized dogs
Comparison
SUN 1165, disopyramide, lorcainide, and mexiletine vs Comparison between the different antiarrhythmic…
Design
Preclinical
Authors
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Caution against clinical use of SUN 1165; leaves open confirmation of class Ic effects in humans.
Does SUN 1165 affect the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles similarly to other antiarrhythmic agents in preclinical models?
SUN 1165 exhibits electrophysiological properties characteristic of class Ic antiarrhythmic agents, with slow kinetics of rate-dependent block of sodium channels.
Hattori et al. (1988) studied this question.
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