January 1, 1987Japanese Heart JournalOpen Access

Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.

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Population

Guinea pig ventricular muscle (papillary muscle), n=5

Design

Preclinical

Authors

JTJunji ToyamaTaisei (Japan)IKItsuo KodamaTokyo Institute of Technology TKTakahiro KusunokiAstellas Pharma (Japan)

Discussion

Member takes

Implication

SUN1165 shows quinidine-like sodium channel kinetics in guinea pig myocytes; leaves open whether these profiles predict clinical antiarrhythmic effects.

Structured PICO

Population

Guinea pig ventricular muscle (papillary muscle), n=5

Intervention

Tocainide (10(-4) M), mexiletine (10(-5) M), and SUN1165 (10(-5) M)

Outcome

Use-dependent blocking actions on the maximum rate of rise of action potentials (Vmax)surrogate

Tocainide and mexiletine exhibit rapid lidocaine-like kinetics, whereas SUN1165 demonstrates slower, quinidine-like kinetics in blocking sodium channels in guinea pig ventricular muscle.

Cite This Study

Toyama et al. (1987) studied this question.

synapsesocial.com/papers/6a7993f1162060f9da88fbea https://doi.org/10.1536/ihj.28.273

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Implication

SUN1165 shows quinidine-like sodium channel kinetics in guinea pig myocytes; leaves open whether these profiles predict clinical antiarrhythmic effects.

Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider