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November 1, 1954Biochemical JournalOpen Access

The determination of creatinine in plasma or serum, and in urine; a critical examination

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Authors

JOJ.A. OwenUniversity of NottinghamBIBetty IggoUniversity of EdinburghFSF. J. ScandrettEdinburgh Royal Infirmary

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Implication

Methodological evaluation examines analytical protocols for measuring creatinine in biological fluids, highlighting key technical factors affecting measurement accuracy.

Key Points

  • Critically evaluate and optimize laboratory techniques used to measure creatinine concentrations in human plasma, serum, and urine.
  • Assessed analytical chemistry protocols for determining creatinine levels in plasma, serum, and urine samples.
  • Evaluated reaction conditions, color development, and potential non-creatinine chromogens causing analytical interference.
  • Identified procedural variables and interfering substances in biological fluids that skew colorimetric creatinine measurements.
  • Outlined specific technical adjustments to standardize reaction conditions and improve assay reliability for clinical assessments.

Cite This Study

Owen et al. (1954) studied this question.

synapsesocial.com/papers/6a7501bdf2cd31a1fadbf2b8https://doi.org/10.1042/bj0580426
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endogenous Creatinine in Serum and Urine.1950 · 484 citations
  2. 2The Determination of Endogenous Creatinine in Plasma and Urine1953 · 77 citations