Key result
Doxorubicin induced mitochondria-mediated intrinsic apoptosis and GPIbα shedding in platelets, which was reduced by the mitochondria-targeted ROS scavenger Mito-TEMPO.
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May support Mito-TEMPO to limit doxorubicin platelet effects; hypothesis-generating for clinical translation.
Wang et al. (2015) studied Doxorubicin-induced thrombocytopenia. Doxorubicin and Mito-TEMPO was evaluated on Platelet apoptosis and GPIbα shedding. Doxorubicin induced mitochondria-mediated intrinsic apoptosis and GPIbα shedding in platelets, which was reduced by the mitochondria-targeted ROS scavenger Mito-TEMPO.
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