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February 1, 1986BloodOpen Access

Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules

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Population

Blood from patients with platelet deficiencies in glycoprotein Ib, IIb-IIIa, or granule substances

Comparison

Ex vivo perfusion of nonanticoagulated and… vs Normal blood

Design

Preclinical

Authors

HWHJ WeissRoche (Switzerland)VTVT TurittoSt. Luke's-Roosevelt Hospital CenterHBHR BaumgartnerRoche (Switzerland)

Discussion

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Implication

Extends mechanistic insight into platelet aggregation in animal models; does not inform clinical practice.

Structured PICO

P
Population
Blood from patients with platelet deficiencies in glycoprotein (GP) Ib, IIb-IIIa (thrombasthenia), or granule substances (storage pool deficiency, SPD)
I
Intervention
Ex vivo perfusion of nonanticoagulated and citrated blood over everted, de-endothelialized rabbit vessel segments at shear rates varying from 650 to 3,300 sec-1
C
Comparator
Normal blood (with or without monoclonal antibody to GPIIb-IIIa)
O
Outcome
Platelet thrombus dimensions and the percentage of the subendothelial surface covered with contact (C) or spread (S) plateletssurrogate

GPIIb-IIIa is essential for platelet-platelet interaction and spreading on the subendothelium, while platelet granules mediate thrombus dimensions.

Cite This Study

Weiss et al. (1986) studied this question.

synapsesocial.com/papers/6a7506ee0b1b00a0ee092427https://doi.org/10.1182/blood.v67.2.322.bloodjournal672322
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules1986 · 174 citations
  2. 2Further Evidence that Glycoprotein IIb-IIIa Mediates Platelet Spreading on Subendothelium1991 · 57 citations
  3. 3Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading1986 · 14 citations
  4. 4Platelet Prothrombinase Activity and Intracellular Calcium Responses in Patients With Storage Pool Deficiency, Glycoprotein IIb-IIIa Deficiency, or Impaired Platelet Coagulant Activity — A Comparison With Scott Syndrome1997 · 80 citations
  5. 5Examination of the roles of glycoprotein Ib and glycoprotein IIb/IIIa in platelet deposition on an artificial surface using clinical antiplatelet agents and monoclonal antibody blockade1991 · 51 citations