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January 1, 1991Thrombosis and Haemostasis

Further Evidence that Glycoprotein IIb-IIIa Mediates Platelet Spreading on Subendothelium

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Key result

Thrombasthenic blood exhibits increased platelet contact, indicating glycoprotein IIb-IIIa mediates platelet spreading on subendothelium.

Population

Blood from patients with thrombasthenia exposed to rabbit aorta subendothelium in an annular chamber

Design

Preclinical

Follow-up

Up to 10 minutes (exposure times of 1, 2, 3, 5, and 10 min)

Authors

HWHarvey J. WeissColumbia UniversityVTVincet T TurittoRoche (Switzerland)HBHans R. BaumgartnerRoche (Switzerland)

Discussion

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Implication

Ex vivo data implicate glycoprotein IIb-IIIa in platelet spreading; leaves open whether this informs antiplatelet strategies in humans.

Study Design

Type

Observational

Structured PICO

P
Population
Patients with thrombasthenia whose blood was evaluated ex vivo for platelet adhesion to subendothelium across multiple exposure times.
E
Exposure
Exposure to subendothelium at a shear rate of 2,600 s-1 for 1, 2, 3, 5, and 10 minutes
O
Outcome
Percent surface coverage of the vessel segment with platelets in the contact (C) and spread (S) stagesurrogate

The study provides conclusive ex vivo evidence that glycoprotein IIb-IIIa mediates platelet spreading on the subendothelium.

Cite This Study

Weiss et al. (1991) conducted an observational in Thrombasthenia. Thrombasthenia (GPIIb-IIIa defect) was evaluated on Percent surface coverage of the vessel segment with platelets in the contact (C) and spread (S) stage. Blood from patients with thrombasthenia exhibited increased platelet contact at all exposure times, providing evidence that glycoprotein IIb-IIIa mediates platelet spreading on subendothelium.

synapsesocial.com/papers/6aa607cc39a5015a928e485dhttps://doi.org/10.1055/s-0038-1647484
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules1986 · 217 citations
  2. 2Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules1986 · 174 citations
  3. 3Examination of the roles of glycoprotein Ib and glycoprotein IIb/IIIa in platelet deposition on an artificial surface using clinical antiplatelet agents and monoclonal antibody blockade1991 · 51 citations
  4. 4Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading1986 · 14 citations
  5. 5Constricted microfluidic devices to study the effects of transient high shear exposure on platelets2017 · 13 citations