Key result
The Roche Cardiac Reader NT-proBNP point-of-care assay showed good correlation (r=0.96; 95% CI 0.94-0.97) and 93% diagnostic concordance compared with the Roche Elecsys laboratory system.
Why the study?
Does the Roche Cardiac Reader NT-proBNP point-of-care assay provide comparable results to the Roche Elecsys NT-proBNP laboratory system in patients with ACS or heart failure?
Observational (n=440)
Does the Roche Cardiac Reader NT-proBNP point-of-care assay provide comparable results to the Roche Elecsys NT-proBNP laboratory system in patients with ACS or heart failure?
The Roche Cardiac Reader NT-proBNP point-of-care assay provides rapid and reliable results comparable to standard laboratory testing, facilitating timely clinical decision-making.
Answers are grounded in this paper and cite their sources.
May support faster NT-proBNP decisions in ACS/HF; leaves open prospective outcome validation.
UNLABELLED: The evaluation of natriuretic peptides has become increasingly valuable in a clinical setting, where information is often needed promptly. OBJECTIVES: To compare the usefulness of the recently released Roche Cardiac Reader NT-proBNP assay against the Roche Elecsys NT-proBNP laboratory system in a clinical setting. DESIGN AND RESULTS: Blood samples from 440 patients, who were either admitted with acute coronary syndromes or worsening heart failure, or who were heart failure outpatients, were evaluated. The relation between the two assays was analysed and the diagnostic concordance calculated. A good correlation was found between the assays (r=0.96, 95% CI: 0.94-0.97) with a diagnostic concordance of 93%. A separate analysis was performed in the range where most clinical decisions are made (60-3000 ng/L), with a diagnostic concordance of 88%. The usefulness in a clinical setting where time is important was high. CONCLUSION: The Roche Cardiac Reader NT-proBNP assay has been evaluated in a clinical setting. The point-of-care method shows good results, although with a restricted analytical range, compared with the reference.
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Alehagen et al. (2008) conducted an observational in Acute coronary syndromes or heart failure (n=440). Roche Cardiac Reader NT-proBNP assay vs. Roche Elecsys NT-proBNP laboratory system was evaluated on Correlation and diagnostic concordance between assays (r=0.96, 95% CI 0.94-0.97). The Roche Cardiac Reader NT-proBNP point-of-care assay showed good correlation (r=0.96; 95% CI 0.94-0.97) and 93% diagnostic concordance compared with the Roche Elecsys laboratory system.
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