Key result
POC analysis of urine NT-proBNP proves feasible and stable for 96 hours.
Why the study?
While bedside serum NT-proBNP point of care testing is established, the analytical capabilities and room-temperature stability of NT-proBNP point of care testing in urine samples required investigation.
Is the cobas h232 point of care system feasible and accurate for determining NT-proBNP in urine samples?
Observational (n=104)
Is the cobas h232 point of care system feasible and accurate for determining NT-proBNP in urine samples?
Point-of-care testing for urine NT-proBNP is feasible and the biomarker is stable at room temperature for at least 96 hours, offering a potential non-invasive diagnostic tool once detection ranges are adjusted.
Answers are grounded in this paper and cite their sources.
May enable non-invasive urine NT-proBNP POC testing; leaves open clinical validation after detection-range adjustment.
INTRODUCTION: The diagnostic potential of urine NT-pro-BNP has been studied recently and shows great promise, especially for children. Bedside serum-NT-proBNP determination with point of care testing (POCT) is established in adults. This study investigated the analytical capabilities of NT-proBNP POCT measurements for urine-samples. Furthermore, the stability of this biomarker in urine samples at room-temperature was explored. METHODS: 104 urine samples were analysed, partly with double and triple determinations and compared to the established Elecsys system. To investigate the stability of NT-proBNP in urine, five samples were stored at room temperature and analysed 12-hourly over 96 h. RESULTS: of 0.84. The stability of urine NT-proBNP was shown with correlation coefficients between 0.97 and 1 (p < 0.001). CONCLUSION: Analysing NT-ProBNP in urine with cobas h232 POC system is feasible, but the detection range needs to be adjusted. As urine NT-proBNP proved stable for at least 96 h even postal shipping would be possible. Adjusting this system's measuring range could help introduce a new, non-invasive, pain-free parameter.
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Müller et al. (2022) reported an observational. cobas h232 POC system vs. Elecsys system was evaluated on Stability of urine NT-proBNP (p=<0.001). Analyzing NT-ProBNP in urine with the cobas h232 POC system is feasible and stable for at least 96 hours (correlation coefficients between 0.97 and 1, p<0.001).
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