Key result
Patients with connective tissue disease demonstrated significantly impaired global longitudinal peak strain (-8.3% vs -10.4%, p=0.001) compared to healthy controls, despite having preserved left ventricular ejection fraction.
Why the study?
The study aimed to assess left ventricular myocardial strain in patients with connective tissue disease and compare left ventricular deformation between idiopathic inflammatory myopathy and non-idiopathic inflammatory myopathy subgroups.
Does 3.0T cardiac MRI tissue tracking detect abnormal left ventricular deformation in patients with connective tissue disease compared to healthy controls?
Cross-Sectional (n=128)
No
Does 3.0T cardiac MRI tissue tracking detect abnormal left ventricular deformation in patients with connective tissue disease compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Cardiac MRI tissue tracking can detect subclinical abnormal left ventricular deformation in patients with connective tissue disease despite preserved ejection fraction.
The aim of this study was to assess left ventricular (LV) myocardial strain in patients with connective tissue disease (CTD) and compare LV deformation between subgroups of idiopathic inflammatory myopathy (IIM) and non-IIM. Ninety-eight patients with CTD, comprising 56 with IIM and 42 with non-IIM, and 30 healthy subjects were enrolled and underwent 3.0T cardiac magnetic resonance imaging (MRI) scanning. The LV function and strain parameters were measured and assessed. Our result revealed that CTD patients had preserved LV ejection fraction (60.85%) and had significantly decreased global and regional peak strain (PS) in radial, circumferential, and longitudinal directions (all p < 0.05). IIM patients showed significantly reduced global longitudinal PS (GLPS) and longitudinal PS at apical slice, whereas all strain parameters decreased in non-IIM patients. Except GLPS and longitudinal PS at apical slice, all strain parameters in non-IIM patients were lower than those in IIM patients. By Pearson's correlation analysis, the LV global radial and circumferential PS were correlated to N-terminal pro-brain natriuretic peptide level and LV ejection fraction in both IIM and non-IIM patients. This study indicated that CTD patients showed abnormal LV deformation despite with preserved LVEF. The impairment of LV deformation differed between IIM and non-IIM patients.
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Wang et al. (2019) conducted a cross-sectional in Connective tissue disease (n=128). Connective tissue disease vs. Healthy controls was evaluated on Global longitudinal peak strain (GLPS) (p=0.001). Patients with connective tissue disease demonstrated significantly impaired global longitudinal peak strain (-8.3% vs -10.4%, p=0.001) compared to healthy controls, despite having preserved left ventricular ejection fraction.
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