In patients with acute myocarditis and preserved LV wall motion, longitudinal strain was significantly reduced compared to healthy controls (-20 vs -25, P<0.0001).
Observational (n=26)
Does acute myocarditis with preserved LV wall motion impair myocardial strain compared to healthy controls?
In patients with acute myocarditis and normal LV wall motion, longitudinal strain is diffusely impaired, highlighting the utility of 2D strain echocardiography for detecting subclinical myocardial dysfunction.
Absolute Event Rate: -20% vs -25%
p-value: p=<0.0001
BACKGROUND: The aim of our study was to assess longitudinal (L), circumferential (C) and radial (R) strain (S) of the left ventricle (LV) in patients with acute myocarditis and preserved LV wall motion. METHODS AND RESULTS: Of the 26 male patients that were enrolled, 13 patients (26+/-8 years) suffered from acute myocarditis and 13 (25+/-2 years) were healthy participants (controls). Both patients and controls underwent cardiac magnetic resonance (CMR) and 2-dimensional S imaging (2D-S) echocardiography on the same day. Myocardial strains (RS, LS and CS) were quantified by 2D-S. In patients with myocarditis, a delayed enhancement (DE) CMR study was performed to identify damaged myocardial segments. In the myocarditis group there was a significant LS reduction compared with controls (-25+/-7 vs -20+/-7, P<0.0001), whereas no difference was found between the 2 groups concerning CS and RS. Subepicardial DE areas were found in 12 of 13 patients. Segments with DE showed a significantly lower LS in comparison with segments without DE (-19+/-4 vs -23+/-6, P<0.0001). In contrast, no difference in CS and RS was found when comparing segments with DE vs segments without DE. CONCLUSIONS: In patients with acute myocarditis, evidence of subepicardial damage and no wall motion abnormalities, longitudinal deformation is diffusely impaired, whereas circumferential impairment is regionally sited in the areas of subepicardial damage.
Bella et al. (Fri,) conducted a observational in Acute myocarditis with preserved LV wall motion (n=26). 2-dimensional strain echocardiography and CMR vs. Healthy controls was evaluated on Longitudinal strain (LS) (p=<0.0001). In patients with acute myocarditis and preserved LV wall motion, longitudinal strain was significantly reduced compared to healthy controls (-20 vs -25, P<0.0001).