Why the study?
Heart failure is characterized by heightened sympathetic activity and diminished parasympathetic activity, making autonomic modulation a promising therapeutic approach.
This review describes neural modulation approaches targeting the autonomic nervous system as potential treatments for heart failure.
Autonomic imbalance in HF supports neuromodulation research; leaves open clinical adoption pending trials.
Heart failure, a condition that arises from numerous cardiovascular disorders, is a primary contributor to mortality related to cardiovascular disease. Typically noticed in heart failure is heightened sympathetic activity coupled with diminished parasympathetic activity. The autonomic nervous system governs the heart’s neurological regulation through opposing functions of its sympathetic and parasympathetic components, which regulate conduction velocity, heart rate, coronary blood flow, and contractile force. Promising treatments for heart failure include inhibiting the sympathetic nerve’s overactivity and restoring parasympathetic activity in the heart. In this review, we describe neural modulation approaches that have potential to assist in the management of heart failure.
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Zhang et al. (2023) studied this question.
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