High-force lengthening contractions cause myofiber injury primarily in the middle portion of the muscle rather than the commonly cited muscle-tendon junction in a rat model.
Challenges muscle-tendon junction emphasis in eccentric injury models; human studies needed before clinical translation.
High-force lengthening contractions are associated with muscle damage and pain, and the muscle-tendon junction is commonly cited as the primary area where myofiber damage occurs. We induced injury in the rat tibialis anterior muscle and acquired magnetic resonance imaging (MRI) images postinjury. We also assayed membrane damage and quantified the number of centrally nucleated myofibers throughout the injured muscles. Results suggest that myofiber injury occurs primarily in the middle portion of the muscle, with interstitial edema in the middle and distal portions.
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Lovering et al. (2009) studied this question.
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