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May 1, 1978American Zoologist

Morphological, Biochemical and Immunohistochemical Studies on Heart Development in Cardiac Mutant Axolotls,Ambystoma mexicanum

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Population

Cardiac mutant axolotls with a naturally-occurring genetic mutation designated 'c' for 'cardiac lethal', and…

Comparison

Addition of tropomyosin to glycerinated mutant… vs Untreated mutant hearts and normal hearts

Design

Preclinical

Authors

LLLarry F. LemanskiEast Texas A&M University

Discussion

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Implication

Tropomyosin may be required for actin filament assembly in cardiac development; leaves open relevance to human cardiomyopathy.

Structured PICO

P
Population
Cardiac mutant axolotls (Ambystoma mexicanum) with a naturally-occurring genetic mutation designated 'c' for 'cardiac lethal', and normal axolotls
I
Intervention
Addition of tropomyosin to glycerinated mutant hearts or homogenates
C
Comparator
Untreated mutant hearts and normal hearts
O
Outcome
Myofibrillogenesis and contractile protein organization (myosin, actin, tropomyosin, α-actinin)surrogate

The absence of tropomyosin in cardiac mutant axolotls prevents normal actin filament formation, which is essential for myofibril organization during heart development.

Cite This Study

Larry F. Lemanski (1978) studied this question.

synapsesocial.com/papers/6a75204501b447f0dadc0360https://doi.org/10.1093/icb/18.2.327
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies of muscle proteins in embryonic myocardial cells of cardiac lethal mutant mexican axolotls (Ambystoma mexicanum) by use of heavy meromyosin binding and sodium dodecyl sulfate polyacrylamide gel electrophoresis.1976 · 26 citations
  2. 2Tropomyosin: a new asymmetric protein component of the muscle fibril1948 · 632 citations