November 26, 2012European Journal of Heart FailureOpen Access

Prediction of Long-Term Outcome of Cardiac Resynchronization Therapy by Acute Pressure–Volume Loop Measurements

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Why the study?

Does acute increase in stroke work during temporary biventricular pacing predict long-term reverse remodelling after CRT in heart failure patients?

Structured PICO

Does acute increase in stroke work during temporary biventricular pacing predict long-term reverse remodelling after CRT in heart failure patients?

Population

41 patients undergoing cardiac resynchronization therapy (CRT), 71% men, NYHA class 2.9 ± 0.4, LVEF 28 ± 7%, QRS 150 ± 25 ms.

Intervention

Invasive assessment of acute haemodynamic response (stroke work and dP/dt(max)) by pressure-volume loop measurements during temporary biventricular pacing before implantation.

Outcome

Long-term response to CRT (reverse remodelling at 6 months).surrogate

Invasive measurement of acute stroke work during biventricular pacing is a reliable predictor of long-term reverse remodelling following CRT.

Discussion

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Implication

Acute stroke work increase may predict CRT response; hypothesis-generating and requires prospective validation before clinical adoption.

Cite This Study

Roest et al. (2012) studied this question.

synapsesocial.com/papers/6a7521d81078cf7de2b1f9cf https://doi.org/10.1093/eurjhf/hfs190

Topics

Heart failure HFrEF treatment

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Prediction of Long-Term Outcome of Cardiac Resynchronization Therapy by Acute Pressure–Volume Loop Measurements

Structured PICO

Discussion

Implication

Cite This Study

Topics

Prediction of Long-Term Outcome of Cardiac Resynchronization Therapy by Acute Pressure–Volume Loop Measurements

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider