Key result
QRS >145 ms, QRS shortening >20 ms, and aortic VTI >14 cm independently predict CRT response.
Why the study?
Prediction of response to cardiac resynchronization therapy in heart failure patients with intraventricular conduction delay using simple ECG and echocardiographic tools was investigated.
Do simple electrocardiographic and echocardiographic parameters predict response to cardiac resynchronization therapy in heart failure patients?
Population
82 consecutive heart failure patients with standard CRT indications
Comparison
Responders vs non-responders to CRT
Design
Observational cohort study
Authors
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May aid CRT responder selection; hypothesis-generating and requires prospective randomized validation before practice change.
Observational (n=82)
Do simple electrocardiographic and echocardiographic parameters predict response to cardiac resynchronization therapy in heart failure patients?
Odds Ratio: 0.95 (95% CI 0.9–0.97)
p-value: p=0.001
Simple ECG and echocardiographic parameters, specifically baseline QRS width, acute QRS shortening, and acute aortic VTI, can independently predict positive clinical and echocardiographic response to CRT.
Bonakdar et al. (2009) conducted an observational in Heart failure and intraventricular conduction delay (n=82). Electrocardiographic and echocardiographic predictors (baseline QRS width, DeltaQRS, aortic VTI) was evaluated on Response to CRT (alive without cardiac decompensation and ≥15% decrease in left ventricular end-systolic volume) (OR 0.95, 95% CI 0.90-0.97, p=0.001). Baseline QRS width >145 ms, QRS shortening >20 ms, and aortic VTI >14 cm independently predicted a positive response to cardiac resynchronization therapy.
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