Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 2006Health Technology AssessmentOpen Access

Measurement of the clinical and cost-effectiveness of non-invasive diagnostic testing strategies for deep vein thrombosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

What is the diagnostic accuracy and cost-effectiveness of non-invasive testing strategies for deep vein thrombosis?

Population

Patients with clinically suspected proximal deep vein thrombosis and isolated calf DVT, or high-risk…

Comparison

Non-invasive diagnostic testing strategies and… vs Alternative diagnostic algorithms or individual…

Design

Meta-analysis

Authors

SGSteve GoodacreUppsala UniversityFSFiona SampsonUniversity of SheffieldMSMatt StevensonThe University of Texas at Tyler

Discussion

Loading...

Member takes

Implication

Supports stepwise DVT testing to limit unnecessary imaging; reinforces Level 1 evidence for guideline algorithms.

Structured PICO

What is the diagnostic accuracy and cost-effectiveness of non-invasive testing strategies for deep vein thrombosis?

P
Population
Patients with clinically suspected proximal deep vein thrombosis (DVT) and isolated calf DVT, or high-risk asymptomatic patients
I
Intervention
Non-invasive diagnostic testing strategies and algorithms (including Wells clinical probability score, D-dimer, ultrasound, plethysmography, rheography, CT scanning, and MRI)
C
Comparator
Alternative diagnostic algorithms or individual tests
O
Outcome
Diagnostic accuracy (sensitivity, specificity, likelihood ratios), clinical effectiveness, and cost-effectiveness (cost per QALY)

Diagnostic algorithms combining Wells score, D-dimer, and ultrasound are highly cost-effective and feasible for diagnosing DVT without requiring substantial service reorganization.

Limitations

  • Cost-effectiveness of the plethysmography algorithm is dependent on assumptions of test independence being met
  • Limited availability of plethysmography and venography at most UK hospitals would require considerable reorganization of services

Cite This Study

Goodacre et al. (2006) studied this question.

synapsesocial.com/papers/6a7539c8a44b96c1f7dbf36fhttps://doi.org/10.3310/hta10150
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Diagnostic Evaluation of Deep Vein Thrombosis2004 · 13 citations
  2. 2Two point-of-care test-based approaches for the exclusion of deep vein thrombosis in general practice: a cost-effectiveness analysis2023 · 5 citations
  3. 3Diagnostic Tests for Deep Vein Thrombosis1994 · 45 citations
  4. 4Diagnostic management of clinically suspected acute deep vein thrombosis2009 · 68 citations
  5. 5Prospective Evaluation of a Screening Protocol to Exclude Deep Vein Thrombosis on the Basis of a Combination of Quantitative D-Dimer Testing and Pretest Clinical Probability Score2005 · 17 citations