2019 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards

Welcome to another of our Eberhard F. Mammen award announcements. As noted many times previously, Thieme, the publisher of Seminars in Thrombosis & Hemostasis (STH), has created the “ Eberhard F. Mammen Excellence in Thrombosis and Hemostasis Awards ” in honor of Eberhard Mammen ([ Fig. 1 ]), and in recognition of his contribution to this field and to the journal that he both founded and steered for over 3 decades ([ Table 1 ]). These awards began in 2009, under two categories; the current award details and conditions are as follows: Most popular article awards: Awarded to the authors of the most popular articles published in STH. The awards are determined by the Editor in Chief on the basis of user statistics from Thieme e-Journals from the preceding 2 years. Prefaces, Errata, Letters to the Editor, and Editorials, and previous award-winning articles, are excluded from further consideration of these awards, which currently comprise two categories—one for “Open Access” articles, and another for “General Category.” There are two major cash prizes of US$1,000 for each category. In addition, winners of the “General Category” awards are granted “open access” status for these articles thereafter. Young Investigator Awards: Best presentation or meeting abstract by a young investigator—as presented or delivered to an international or large regional meeting on a topic related to the fields of thrombosis and hemostasis, and whose subject matter is determined to be in the spirit of Dr Mammen, up to six cash prizes of US$1,000 in any year. There are some additional considerations and conditions for the award, and awardees are expected to prepare a review or other paper related to the topic of their presentation (or as otherwise agreed) for publication in STH. In general, previous award winners are excluded from a second award to enable more individuals to be recognized. After nominations are received, the awardees are selected by a vote of the senior editors of STH. Any potential conflicts of interests are managed by first identifying these, and then excluding those with potential conflicts from voting. Fig. 1 Eberhard F. Mammen (1930–2008). Table 1 Listing of relevant editorials published in STH as related to the initiation of the Eberhard F. Mammen awards, as well as previous award announcements 1. Favaloro EJ. Welcome to a special issue of seminars in thrombosis and hemostasis—the closing issue for 2008. Semin Thromb Hemost 2008;34:693–696 2. Favaloro EJ. A tribute to Eberhard F. Mammen, MD (1930–2008). Semin Thromb Hemost 2008;34:703–708 3. Favaloro EJ. Welcome to the first issue of seminars in thrombosis and hemostasis for 2009. Semin Thromb Hemost 2009;35:1–2 4. Favaloro EJ. Winners of the inaugural Eberhard F. Mammen award for most popular article. Semin Thromb Hemost 2009;35:587–590 5. Favaloro EJ. 2009 Eberhard F. Mammen Young Investigator Award Winners. Semin Thromb Hemost 2010;36:469–470 6. Favaloro EJ. Winners of the 2010 Eberhard F. Mammen award for most popular article during 2008–2009. Semin Thromb Hemost 2010;36(7):685–692 7. Favaloro EJ. 2011 Eberhard F. Mammen award announcements. Semin Thromb Hemost 2011;37(5):431–439 8. Favaloro EJ. 2012 Eberhard F. Mammen award announcements. Semin Thromb Hemost 2012;38:425–432 9. Favaloro EJ. 2013 Eberhard F. Mammen award announcements. Semin Thromb Hemost 2013;39:567–574 10. Favaloro EJ. 2014 Eberhard F. Mammen award announcements: part I-most popular articles. Semin Thromb Hemost 2014;40(4):407–412 11. Favaloro EJ. 2014 Eberhard F. Mammen award announcements: part II—Young Investigator Awards. Semin Thromb Hemost 2014;40(7):718–723 12. Favaloro EJ. 2015 Eberhard F. Mammen award announcements: part I-most popular articles. Semin Thromb Hemost 2015;41(7):673–679 13. Favaloro EJ. 2015 Eberhard F. Mammen award announcements: part II-Young Investigator Awards. Semin Thromb Hemost 2015;41(8):809–815 14. Favaloro EJ. 2016 Eberhard F. Mammen award announcements: part I—most popular articles. Semin Thromb Hemost 2016;42(4):325–330 15. Favaloro EJ. 2016 Eberhard F. Mammen award announcements: part II-Young Investigator Awards. Semin Thromb Hemost 2017;43(3):235–241 16. Favaloro EJ. 2017 Eberhard F. Mammen award announcements: part I-most popular articles. Semin Thromb Hemost 2017;43(4):357–363 17. Favaloro EJ. 2017 Eberhard F. Mammen award announcements: part II-Young Investigator Awards. Semin Thromb Hemost 2018;44(2):81–88 18. Favaloro EJ. 2018 Eberhard F. Mammen award announcements: part I-most popular articles. Semin Thromb Hemost 2018;44(3):185–192 19. Favaloro EJ. 2018 Eberhard F. Mammen award announcements: part II-Young Investigator Awards. Semin Thromb Hemost 2019;45(2):123–129 20. Favaloro EJ. 2019 Eberhard F. Mammen award announcements: part I-most popular articles. Semin Thromb Hemost 2019;45(3):215–224 Further details of the awards and the award winners are posted online (< https://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000077 >), and previous award winner announcements are also available in print (see [ Table 1 ] for a listing of relevant editorials published in this journal as related to the initiation of the Eberhard F. Mammen awards, as well as previous award announcements; these publications are also available for free download from the journal Web site: < https://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000077 >). The winners of the 2019 Eberhard F. Mammen awards for the most popular articles from STH for the period of 2017 to 2018 inclusive were announced in an earlier issue of the journal.[ 1 ] It is therefore with great pleasure that we would like to announce the winners of the latest round of Young Investigator Awards. As mentioned above, the Young Investigator Awards represent winners of the best presentation or meeting abstract by a young investigator—as presented or delivered to an international or large regional meeting on a topic related to the fields of thrombosis and hemostasis, and whose subject matter is determined to be in the spirit of Dr Mammen. There are additional considerations given that the nominees' presentations are not always seen by all of the possible award nominators, being drawn from the editorial team of the journal. The latest winners are identified below and also in [ Table 2 ], with a running list of previous awardees, and the resulting publications in the journal, given in [ Table 3 ]. The latest awardees are derived from a variety of meetings, but primarily the latest meeting of the International Society on Thrombosis and Haemostasis (ISTH) held in Melbourne, Australia, in July 2019 (ISTH 2019). Table 2 Latest (2019) Eberhard F. Mammen Young Investigator Award winners Awardee Current affiliation(s) Presentation(s) awarded Proposed submission to STH Elisa Danese, PharmD, PhD Department of Neurological, Biomedical and Movement Sciences, University of Verona, and Clinical Biochemistry Section, Hospital G.B. Rossi, Verona, Italy ISTH2019. Presentation: epigenetics in hemostasis. The role of epigenetics in the regulation of hemostatic balance. Soracha Ward, BSc (Hons) (PhD candidate) Trinity College, and Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland 2018 American Society of Haematology Conference (San Francisco). Presentation: defining the molecular mechanisms through which the macrophage galactose lectin (MGL) receptor regulates von Willebrand factor clearance. Lectin receptors—key modulators of VWF and FVIII biology. Jonathan Douxfils, M Pharm Sc, PhD University of Namur, CEO & Founder of QUALIblood, Belgium ISTH2019. Presentation: a new algorithm based on thrombin generation to assess hormone-related prothrombotic changes. 11th ECAT meeting—Leiden (Netherlands; 2018) presentation: interference of DOACs on coagulation tests. Venous thromboembolism and oral contraceptives: focus on testing that may enable prediction and assessment of the risk. Erik Klok, MD PhD Internist, Vascular Medicine specialist, Dept. of Medicine, Thrombosis and Hemostasis, Leiden University Medical Center ISTH2019. Presentation: evaluation of the predictive value of the bleeding prediction score “VTE-BLEED” for recurrent venous thromboembolism. Early diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: state of the art and implications for daily practice. Michelle Lavin, MD PhD Irish Centre for Vascular Biology, Department of Molecular & Cellular Therapeutics, RSCI, Dublin, Ireland ISTH2019. Presentation: VWD and pregnancy—results of an International Survey. Areas of clinical uncertainty in the management of pregnancy for women with von Willebrand disease. Deeksha Khialani, M BioMed Sc (PhD candidate) Department of Clinical Epidemiology at Leiden University Medical Center (LUMC), Netherlands ISTH2019. Presentation: thrombosis risk after switching oral contraceptive type. Hormonal contraceptives and the risk of venous thrombosis. Abbreviations: DOACs, direct oral anticoagulants; ISTH2019, International Society on Thrombosis and Haemostasis (ISTH) held in Melbourne, Australia, in July 2019; STH, Seminars in Thrombosis & Hemostasis; VTE, venous thromboembolism; VWD, von Willebrand disease; VWF, von Willebrand factor. Table 3 Eberhard F. Mammen Young Investigator Award winners from previous years Awardee Year awarded Publication arising Willem M. Lijfering 2009 Lijfering WM, Flinterman LE, Vandenbroucke JP, Rosendaal FR, Cannegieter SC. Relationship between venous and arterial thrombosis: a review of the literature from a causal perspective. Semin Thromb Hemost 2011;37(8):885–896 Salley Pels 2009 Pels SG. Current therapies in primary immune thrombocytopenia. Semin Thromb Hemost 2011;37(6):621–630 Adam Cuker 2010 Cuker A. Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost 2012;38(1):31–37 Giridhara Rao Jayandharan 2010 Jayandharan GR, Srivastava A, Srivastava A. Role of molecular genetics in hemophilia: from diagnosis to therapy. Semin Thromb Hemost 2012;38(1):64–78 Timea Szanto 2010 Szántó T, Joutsi-Korhonen L, Deckmyn H, Lassila R. New insights into von Willebrand disease and platelet function. Semin Thromb Hemost 2012;38(1):55–63 Birgitta Salmela 2010 Salmela B, Joutsi-Korhonen L, Armstrong E, Lassila R. Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis. Semin Thromb Hemost 2012;38(1):23–30 Pia Riittaa-Maria Siljander 2010 Aatonen M, Grönholm M, Siljander PR. Platelet-derived microvesicles: multitalented participants in intercellular communication. Semin Thromb Hemost 2012;38(1):102–113 Romaric Lacroix 2011 Lacroix R, Dignat-George F. Microparticles: new protagonists in pericellular and intravascular proteolysis. Semin Thromb Hemost 2013;39(1):33–39 Brad McEwen 2011 McEwen BJ, Morel-Kopp MC, Chen W, Tofler GH, Ward CM. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. Semin Thromb Hemost 2013;39(1):25–32 Neil A. Goldenberg 2011 Bernard TJ, Armstrong-Wells J, Goldenberg NA. The institution-based prospective inception cohort study: design, implementation, and quality assurance in pediatric thrombosis and stroke research. Semin Thromb Hemost 2013;39(1):10–14 Vivien Chen 2011 Chen VM. Tissue factor de-encryption, thrombus formation, and thiol-disulfide exchange. Semin Thromb Hemost 2013;39(1):40–47 Joseph E. Italiano, Jr. 2011 Italiano JE Jr. Unraveling mechanisms that control platelet production. Semin Thromb Hemost 2013;39(1):15–24 Vivian Xiaoyan Du 2012/2013 Du VX, Huskens D, Maas C, Al Dieri R, de Groot PG, de Laat B. New insights into the role of erythrocytes in thrombus formation. Semin Thromb Hemost 2014;40(1):72–80 Andrew Yee 2012/2013 Yee A, Kretz CA. Von Willebrand factor: form for function. Semin Thromb Hemost 2014;40(1):17–27 Sarah O'Brien 2012/2013 O'Brien SH. Contraception-related venous thromboembolism in adolescents. Semin Thromb Hemost 2014;40(1):66–71 Veronica Flood 2012/2013 Flood VH. Perils, problems, and progress in laboratory diagnosis of von Willebrand disease. Semin Thromb Hemost 2014;40(1):41–48 Julie Tange 2012/2013 Tange JI, Grill D, Koch CD, et al. Local verification and assignment of mean normal prothrombin time and international sensitivity index values across various instruments: recent experience and outcome from North America. Semin Thromb Hemost 2014;40(1):115–120 Kent Chapman 2012/2013 Chapman K, Yuen S. Therapy for thrombotic thrombocytopenia purpura: past, present, and future. Semin Thromb Hemost 2014;40(1):34–40 Andreas Tiede 2014 Tiede A, Werwitzke S, Scharf RE. Laboratory diagnosis of acquired hemophilia a: limitations, consequences, and challenges. Semin Thromb Hemost 2014;40(7):803–811 Wendy Lim 2014 Lim W. Thrombotic risk in the antiphospholipid syndrome. Semin Thromb Hemost 2014;40(7):741–746 Susana Nobre Fernandes 2014 Fernandes S, Carvalho M, Lopes M, Araújo F. Impact of an individualized prophylaxis approach on young adults with severe hemophilia. Semin Thromb Hemost 2014;40(7):785–789 Maria Elisa Mancuso 2014 Mancuso ME, Fasulo MR. Thrombin generation assay as a laboratory monitoring tool during by-passing therapy in patients with hemophilia and inhibitors. Semin Thromb Hemost 2016;42(1):30–35 Coen Maas 2014 Tersteeg C, Fijnheer R, Deforche L, et al. Keeping von Willebrand factor under control: alternatives for ADAMTS13. Semin Thromb Hemost. 2016;42(1):9–17 Riten Kumar 2014 Kumar R, Dunn A, Carcao M. Changing paradigm of hemophilia management: extended half-life factor concentrates and gene therapy. Semin Thromb Hemost 2016;42(1):18–29 Juraj Sokol 2015 Sokol J, Skerenova M, Jedinakova Z, et al. Progress in the understanding of sticky platelet syndrome. Semin Thromb Hemost 2017;43(1):8–13 Ljubica Jovanović 2015 Jovanovic L, Antonijevic N, Novakovic T, et al. Practical aspects of monitoring of antiplatelet therapy. Semin Thromb Hemost 2017;43(1):14–23 Lucia Stanciakova 2015 Stanciakova L, Dobrotova M, Jedinakova Z, et al. Monitoring of hemostasis and management of anticoagulant thromboprophylaxis in pregnant women with increased risk of fetal loss. Semin Thromb Hemost 2016;42(6):612–621 Tina Biss 2015 Biss TT. Venous thromboembolism in children: is it preventable? Semin Thromb Hemost 2016;42(6):603–611 Tobias Fuchs 2015 Jiménez-Alcázar M, Kim N, Fuchs TA. Circulating extracellular DNA: cause or consequence of thrombosis? Semin Thromb Hemost 2017;43(6):553–561 Jonathan M. Coutinho 2015 Silvis SM, Middeldorp S, Zuurbier SM, Cannegieter SC, Coutinho JM. Risk factors for cerebral venous thrombosis. Semin Thromb Hemost 2016;42(6):622–631 Soundarya Selvam 2016 Selvam S, James P. Angiodysplasia in von Willebrand disease: understanding the clinical and basic science. Semin Thromb Hemost 2017;43(6):572–580 Vincent Muczynski 2016 Muczynski V, Christophe OD, Denis CV, Lenting PJ. Emerging therapeutic strategies in the treatment of hemophilia A. Semin Thromb Hemost 2017;43(6):581–590 Karen Schreiber 2016 Schreiber K, Breen K, Cohen H, et al. HYdroxychloroquine to improve pregnancy outcome in women with AnTIphospholipid antibodies (HYPATIA) protocol: a multinational randomized controlled trial of hydroxychloroquine versus placebo in addition to standard treatment in pregnant women with antiphospholipid syndrome or antibodies. Semin Thromb Hemost 2017;43(6):562–571 Jasmine Wee Ting Tay 2016 Tay J, Tiao J, Hughes Q, Jorritsma J, Gilmore G, Baker R. Circulating MicroRNA as thrombosis sentinels: caveats and considerations. Semin Thromb Hemost 2018;44(3):206–215 Adi J. Klil-Drori 2016 Klil-Drori AJ, Tagalakis V. Direct oral anticoagulants in end-stage renal disease. Semin Thromb Hemost 2018;44(4):353–363 Lindsey A. George 2016 Submission pending. Ivar van Asten 2017 van Asten I, based platelet function Semin Thromb Hemost 2017 Submission pending. 2017 E, K, extracellular in arterial and venous thrombosis. Semin Thromb Hemost 2017 R, J, thrombotic purpura: a review of diagnosis and treatment in Semin Thromb Hemost In 2017 Favaloro J. or oral anticoagulants to bleeding risk a review of and Semin Thromb Hemost 2017 Submission pending. 2018 M, for the direct factor mechanisms of current and emerging Semin Thromb Hemost In James PhD 2018 H, as in an role and defining a new Semin Thromb Hemost BSc PhD 2018 Submission pending. 2018 J, Sokol J, T, et al. of von Willebrand disease: current state and Semin Thromb Hemost In MD 2018 T, M, I, et al. and on bleeding and Semin Thromb Hemost BSc (Hons) 2018 Submission pending. As with these awards, the current of winners a variety of at various of their some awardees are on their in or are in their and over into the of their be Dr Elisa ([ Fig. 2 in and currently as of Clinical Biochemistry at the University of has a in a in Clinical Biochemistry and a PhD in and has published over articles in and has in more and international is also a current of the international journal of for a as a presentation at ISTH2019. Fig. 2 Young Investigator Award winner Elisa Soracha Ward ([ Fig. 3 is a PhD in the Irish Centre for Vascular in with a BSc in Biomedical from University College in the Haemostasis in Trinity College, primarily on the role of von Willebrand factor in As published in the journal to the of a VWF macrophage galactose 2 ] Soracha has presented at both international and meetings, for which has In an abstract award and as of at the meeting of the American Society of that the basis of for the 2019 Eberhard F. Mammen Fig. 3 Young Investigator Award winner Soracha Jonathan ([ Fig. his PhD in and in In he an at the on the of for the laboratory of direct oral anticoagulants in the by in the field of thrombosis and hemostasis. also his as a at the Medicine is of the of and a and CEO of QUALIblood, a to and with for and clinical and laboratory he is in current to improve the and of therapeutic to Dr has the of two nominations for the 2019 ([ Table 2 ]). Fig. Young Investigator Award winner Jonathan Erik ([ Fig. has in the management of venous thromboembolism on of management of and of from into clinical practice. are relevant for or clinical pregnant the and patients with The of being a clinical in Leiden and a in the Center for Thrombosis and Hemostasis in Dr to in and large international and In addition to Dr is in and both and PhD Dr for a 2019 an Fig. Young Investigator Award winner Erik Michelle ([ Fig. awarded in from the University of Ireland, and a in coagulation of the College of in awarded in 2017 from Trinity College Dublin, on clinical and basis of current the and clinical of bleeding as a Clinical in the Irish Centre for Vascular Biology, Dr is to and for with bleeding Dr also for a 2019 an Fig. Young Investigator Award winner Michelle Deeksha ([ Fig. is another PhD but at the Department of Clinical Epidemiology at Leiden University Medical Center (LUMC), has a in Biomedical Sciences, with a special in current on large of to the of contraceptives and risk of of women is to these women and their with the most the form of are to also assess the between contraceptives and risk of other Deeksha also for a 2019 an Fig. Young Investigator Award winner Deeksha award winners were to that selected to an Eberhard F. Mammen Young Investigator and the additional is pleasure and to and selected for the Eberhard F. Mammen Young Investigator the that this award has to many years of in the field of would also like to the Editor in Chief of Seminars in Thrombosis and Hemostasis Dr for this as well as and for their and and for and and in thrombosis and hemostasis Elisa ([ Fig. 2 to for and awarded an Eberhard F. Mammen Young Investigator would like to the editorial team of Seminars in Thrombosis and Hemostasis for this would not possible the of in the Irish Centre of Vascular Biology, in James Soracha Ward ([ Fig. 3 to be awarded an Eberhard F. Mammen Young Investigator the recognition of the for and current is a great which would not possible the of team and the that to In and and would also like to and for our and on hemostasis award a team and the that has into these Jonathan ([ Fig. to an Eberhard F. Mammen Young Investigator the recognition for research. award a team by It is a pleasure to the award on their an award that our Erik ([ Fig. the first Irish to be awarded an Eberhard F. Mammen Young Investigator to this for on in women with von Willebrand disease in the Irish Centre for Vascular at to to for with bleeding strategies for women with VWD is a focus of the VWF and of the with on this would like to all of those in this to and to in our and in this Michelle ([ Fig. and for being awarded an Eberhard F. Mammen Young Investigator award team and the that has into this would to Dr van and Rosendaal for their and In addition, this would not possible de a and an at our Department of Clinical Deeksha ([ Fig. In with previous the Young Investigator awardees from previous years as well as the outcome of their to STH, as in [ Table 3 ]. The most recent are in the 3 ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] mentioned that most of the from earlier years in further some of these or the young of the most popular It is also to that of the Young Investigator awardees were on other to STH that were also in these most popular to the of the current and winners to to The noted also that for Young Investigator awardees, and all awardees best of to the by earlier award