2016 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards

Welcome to another of our Eberhard F. Mammen Award announcements. As noted previously,[ 1 ] [ 2 ] [ 3 ] Thieme, the publisher of Seminars in Thrombosis & Hemostasis , has created the “ Eberhard F. Mammen Excellence in Thrombosis and Hemostasis Awards ” in honor of Eberhard Mammen ([ Fig. 1 ]) and in recognition of his contribution to this field and to the journal that he founded and steered for over three decades. These awards began in 2009, under two categories; the current award details and conditions are as follows: Fig. 1 Eberhard F. Mammen (1930–2008). Most Popular Article Award: Awarded to the authors of the most popular articles published in Seminars in Thrombosis & Hemostasis . The awards are determined by the Editor in Chief on the basis of user statistics from Thieme e-Journals from the preceding 2 years. Prefaces, Errata, Letters to the Editor, Editorials, and previous award winners are excluded from further consideration of these awards, which currently comprise two categories: one for “Open Access” articles and another for a “General Category.” There are two major cash prizes of US$1,000 for each category. In addition, winners of the “General Category” awards are granted “open access” status for these articles thereafter. Young Investigator Award: Best presentation or meeting abstract by a young investigator—as presented or delivered to an international or large regional meeting on a topic related to the fields of thrombosis and hemostasis, and whose subject matter is determined to be in the spirit of Dr. Mammen—up to six cash prizes of US$1,000 in any year. There are some additional considerations and conditions for the award, and awardees are expected to prepare a review or other paper related to the topic of their presentation (or as otherwise agreed) for publication in Seminars in Thrombosis & Hemostasis . Further details of the awards and the award winners are posted online (< http://www.thieme.com/sth >), and previous award winner announcements are also available in print.[ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ] [ 10 ] [ 11 ] [ 12 ] [ 13 ] [ 14 ] The winners of the 2016 Eberhard F. Mammen awards for the most popular articles from Seminars in Thrombosis & Hemostasis for the period of 2014–2015 inclusive were announced in an earlier issue,[ 14 ] and the awards for the most popular articles from Seminars in Thrombosis & Hemostasis for the period of 2015–2016 inclusive will be announced in the next issue of the journal.[ 15 ] It is therefore with great pleasure that we would like to announce the winners of the latest round of Young Investigator Awards related to meetings held in the recent past. As this announcement has been delayed, being scheduled for late last year, there are actually more than six awardees, and so this announcement will cover both the 2016 awardees plus one 2017 awardee. As mentioned previously, the Young Investigator Awards represent winners of the best presentation or meeting abstract by a young investigator—as presented or delivered to an international or large regional meeting on a topic related to the fields of thrombosis and hemostasis, and whose subject matter is determined to be in the spirit of Dr. Mammen. There are additional considerations given that the nominees' presentations are not always seen by all of the possible award nominators, being drawn from the editorial team of the journal. The latest winners are identified below and also listed in [ Table 1 ]. The awardees were derived from several meetings. Table 1 Latest Young Investigator Awardees Awardee Current placement Presentation(s) awarded Meeting presented Soundarya Selvam Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada Blood outgrowth endothelial cells from type 3 von Willebrand disease patients display abnormal angiogenesis ISTH SSC 2016 (International Society on Thrombosis and Hemostasis Scientific and Standardization Committee congress Montpellier, France, May 2016) Vincent Muczynski Inovarion/INSERM U1176-HITh; CHU-Bicêtre, Le Kremlin-Bicêtre, France A novel factor VIII–nanobody fusion protein displaying prolonged half-life and hemostatic efficacy in vivo Karen Schreiber St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, UK HYPATIA—A prospective randomized controlled trial of HYdroxychloroquine versus placebo during Pregnancy in women with AnTIphospholipid Antibodies Adi J. Klil-Drori McGill University, Montreal, QC, Canada; and Jewish General Hospital, Montreal, Canada The Risk of Major Bleeding with Low-Molecular-Weight-Heparins for Venous Thromboembolism in Dialysis Patients: The Q-VTE Study 2016 ASH (American Society of Hematology, December 2016, USA) Lindsey A. George The Children's Hospital of Philadelphia, Philadelphia, PA Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B Achieves Sustained Mean Factor IX Activity Levels of >30% without Immunosuppression Jasmine Wee Ting Tay Western Australian Centre for Thrombosis and Haemostasis (WACTH), Murdoch University, Perth, Australia Validation of plasma miR-494–3p and miR-365a-3p expression levels as indicators of thrombotic risk HAA 2016 ( H aematology Society of Australia and New Zealand, A ustralian & New Zealand Society of Blood Transfusion and the A ustralasian Society of Thrombosis and Haemostasis; November 2016, Melbourne, Australia) Ivar van Asten University Medical Center Utrecht, Utrecht, The Netherlands Diagnostic value of a flow cytometry-based platelet function test compared with light transmission aggregometry in patients with unknown bleeding disorders ISLH 2016 (the XXIXth International Symposium on Technological Innovations in Laboratory Hematology; May 2016, Milan, Italy) Soundarya Selvam ([ Fig. 2 ]) is a graduate of the University of Western Ontario (BSc (Hon), 2014), and currently a doctoral candidate under the supervision of Dr. Paula James at Queen's University. Her main research interests are von Willebrand factor regulation of angiogenesis and circulating endothelial progenitors in von Willebrand disease and cardiovascular disease. In addition to her research activities, Soundarya also supervises undergraduate students for their fourth-year thesis projects and is an enrichment studies unit instructor engaged in teaching elementary and high school students about human pathologies. Fig. 2 Young Investigator Award winner Soundarya Selvam. Vincent Muczynski ([ Fig. 3 ]) graduated with his PhD from Paris-Sud University in 2011, focusing on the effects of endocrine disruptor exposure on the development of the reproductive function. Next, he moved to the field of hemostasis during a 4-year postdoctoral experience under the mentorship of Dr. Olivier Christophe. During this period, he investigated the mechanisms that regulate the clearance and protection of coagulation factor X. He has been an Inovarion young investigator (since early 2016) in the laboratory of Dr. Cécile Denis. Under the supervision of Dr. Peter Lenting, he aims to help develop bioengineered therapeutic FVIII molecules as alternative options in the treatment of hemophilia A. Fig. 3 Young Investigator Award winner Vincent Muczynski. Karen Schreiber ([ Fig. 4 ]) is a clinical research fellow at the Thrombosis and Haemostasis Centre, St Thomas' Hospital, London. She graduated from Aarhus University in Denmark in 2008 and is currently undertaking her PhD, from the Universities of Copenhagen and London. Her main interests are thrombosis and pregnancy complications in antiphospholipid syndrome. Dr. Schreiber is a board member of the EMEUNET/EULAR, an international network of young rheumatologists; a member of the British Society for Rheumatology working group publishing guidelines on “prescribing anti-rheumatic drugs in pregnancy”; and is managing HYPATIA—a randomized clinical trial on the utility of hydroxychloroquine in mothers with antiphospholipid antibodies. Fig. 4 Young Investigator Award winner Karen Schreiber. Adi J. Klil-Drori ([ Fig. 5 ]) is a fellow at the Clinical Research Unit of the Jewish General Hospital in Montreal, Canada. He received his MD in 2007 from the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology. After completing internal medicine and hematology training at the Rambam Health Care Campus in Haifa, Israel, he spent 2 years as a research fellow in clinical epidemiology at McGill University. He holds a Young Investigator Award from the American Society of Clinical Oncology and fellowship awards from the Israeli Cancer Research Foundation and the Canadian Venous Thromboembolism Clinical Trials and Outcome Research Network. His research focus is on drug outcomes in venous thrombosis and hematologic malignancies. Fig. 5 Young Investigator Award winner Adi J. Klil-Drori. Lindsey George ([ Fig. 6 ]) is a hematologist at the Children's Hospital of Philadelphia (CHOP) and Instructor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, Pennsylvania. She completed a pediatric and chief residency at Weill Cornell Medical College and Hematology/Oncology training at CHOP. She initially pursued laboratory training at Dr. Katherine High studying hemophilia gene therapy and has continued basic science training in coagulation biochemistry under the mentorship of Dr. Rodney Camire. She is interested in developing novel therapeutics for hemophilia and is the principal investigator of adeno-associated virus (AAV)-mediated gene transfer trials for both hemophilia A and B. Fig. 6 Young Investigator Award winner Lindsey George. Jasmine Tay ([ Fig. 7 ]) is a postdoctoral scientist and the corecipient of the 2015 Caruso Family Postdoctoral Research Fellowship at the West Australian Centre for Thrombosis and Haemostasis located in Murdoch University. She received her PhD from the UWA School of Pathology and Laboratory Medicine in 2013, which investigated the efficacy of androgens in the treatment of poor prognosis breast tumors. Jasmine has continued to pursue her interest in steroid hormone signaling in disease and joined Prof. Ross Baker's Laboratory to study estrogen-regulated microRNAs associated with venous thrombosis during pregnancy and the role of circulating miRNAs in regulating hemostasis. Fig. 7 Young Investigator Award winner Jasmine Tay. Ivar van Asten ([ Fig. 8 ]) is a PhD student at the Department of Clinical Chemistry and Hematology at the University Medical Center Utrecht in the Netherlands. After his graduation in 2015, he started his PhD study on platelet function disorders and is part of the Thrombocytopathy in the Netherlands (TiN) study group. The main focus of his project is to improve the diagnostic workup in patients with (suspected) platelet function disorders and to identify new mechanisms that contribute to the patient's bleeding phenotype. Fig. 8 Young Investigator Award winner Ivar van Asten. All award winners were thrilled to hear that they had been selected to receive an Eberhard F. Mammen Young Investigator Award, and provided the following additional commentary: It was with elated surprise and joy that I realized I had been nominated and acknowledged for the 2016 Eberhard F. Mammen Young Investigator Award. This award recognizes a truly collaborative effort and could not have come to fruition without the contributions of Dr. Mackenzie Bowman and Lara Casey. I would also like to extend my gratitude to my supervisor, Dr. Paula James, for giving me the opportunity to explore my research interests in her lab and for her unwavering support. — Soundarya Selvam ([ Fig. 2 ]) I am deeply honored to be a recipient of a 2016 Eberhard F. Mammen Young Investigator Award. Beyond the individual recognition, this nomination acknowledges the team effort of all my colleagues in our laboratory. On a daily basis, they are essential actors of the scientific contribution that we attempt to make to the dynamic field of Thrombosis and Haemostasis. I am grateful to them. — Vincent Muczynski ([ Fig. 3 ]) I am very excited and honored to have received an Eberhard F. Mammen Young Investigator Award. It is with deepest appreciation that I express my thanks for being chosen to receive this prestigious award. My presentation was an introduction to our “HYPATIA study”, which will investigate the role of hydroxychloroquine in pregnant women with antiphospholipid syndrome. This award recognizes not just my efforts, but the efforts of my team and in particular my supervisor Prof. Beverley Hunt who is a true inspiration! — Karen Schreiber ([ Fig. 4 ]) I am thrilled and honored to join a prestigious list of recipients of this award. Our study on the risk of major bleeding with low-molecular-weight-heparins (LMWH) for venous thromboembolism in dialysis patients highlights a vulnerable population with a unique set of bleeding and thrombotic risks. It also reports on real-world utilization of LMWH in this population despite a perceived contraindication, warranting further investigation. I would like to thank my mentor Dr. Vicky Tagalakis for her inspiration and support, and to acknowledge the CanVECTOR Network for the opportunity to be part of a world-class thrombosis research collaboration. — Adi J. Klil-Drori ([ Fig. 5 ]) I deeply appreciate this award. It was an honor to present the preliminary results of SPK-9001, a Phase I/II trial of adeno-associated virus mediated factor IX gene transfer for hemophilia B, at the American Society of Hematology scientific plenary. This study builds on two decades of pre-clinical and clinical investigation of gene therapy for hemophilia led by Dr. Katherine High and represents the cumulative efforts of a large group of talented investigators. — Lindsey George ([ Fig. 6 ]) It was an incredible surprise to be nominated, and a huge honour to have received the award. This award supports our research investigating microRNAs contributing to pregnancy-associated acquired Protein S deficiency and thrombotic risk, and helps to showcase some of the work being carried out at the Western Australian Centre for Thrombosis and Haemostasis (WACTH) in Murdoch University. I would like to take this opportunity to acknowledge my supervisor Prof. Ross Baker and all my colleagues at WACTH for their ongoing support and contribution to this work. — Jasmine Tay ([ Fig. 7 ]) I am absolutely honored being rewarded for one of the Eberhard F. Mammen awards. It feels great that our efforts are being appreciated and it gives extra motivation to move on with our research to improve platelet function diagnostics. I would like to thank all the coauthors for their contributions and special thanks to my supervisors Dr. Rolf Urbanus and Prof. Roger Schutgens. — Ivar van Asten ([ Fig. 8 ]) In keeping with previous editorials, I have again reviewed the Young Investigator Awardees from previous years as well as the outcome of their subsequent submissions[ 15 ] [ 16 ] [ 17 ] [ 18 ] [ 19 ] [ 20 ] [ 21 ] [ 22 ] [ 23 ] [ 24 ] [ 25 ] [ 26 ] [ 27 ] [ 28 ] [ 29 ] [ 30 ] [ 31 ] [ 32 ] [ 33 ] [ 34 ] [ 35 ] [ 36 ] [ 37 ] [ 38 ] [ 39 ] [ 40 ] [ 41 ] [ 42 ] [ 43 ] to Seminars in Thrombosis & Hemostasis , and as summarized in [ Table 2 ]. I previously mentioned my personal gratification that most of the articles from earlier years have subsequently appeared in several annual top 100 listings.[ 9 ] [ 10 ] [ 12 ] [ 14 ] [ 44 ] Of further interest, one of these articles actually won one of the Most Popular Awards in 2014 (within the “Open Access” category) and based on the “most popular” 2012–2013 list.[ 21 ] Also motivating is that a few of the Young Investigator awardees were also included as authors on other contributions to Seminars in Thrombosis & Hemostasis that were also listed in these most popular listings, including another 2014 Most Popular Award winner.[ 45 ] Table 2 Young Investigator Awardees from previous years Awardee Year awarded Publication arising Willem M. Lijfering 2009 Lijfering WM, Flinterman LE, Vandenbroucke JP, Rosendaal FR, Cannegieter SC. Relationship between venous and arterial thrombosis: a review of the literature from a causal perspective. Semin Thromb Hemost 2011;37(8):885–896 Salley Pels 2009 Pels SG. Current therapies in primary immune thrombocytopenia. Semin Thromb Hemost 2011;37(6):621–630 Adam Cuker 2010 Cuker A. Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost. 2012;38(1):31–37 Giridhara Rao Jayandharan 2010 Jayandharan GR, Srivastava A, Srivastava A. Role of molecular genetics in hemophilia: from diagnosis to therapy. Semin Thromb Hemost 2012;38(1):64–78 Timea Szanto 2010 Szántó T, Joutsi-Korhonen L, Deckmyn H, Lassila R. New insights into von Willebrand disease and platelet function. Semin Thromb Hemost 2012;38(1):55–63 Birgitta Salmela 2010 Salmela B, Joutsi-Korhonen L, Armstrong E, Lassila R. Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis. Semin Thromb Hemost 2012;38(1):23–30 Pia Riittaa-Maria Siljander 2010 Aatonen M, Grönholm M, Siljander PR. Platelet-derived microvesicles: multitalented participants in intercellular communication. Semin Thromb Hemost 2012;38(1):102–113 Romaric Lacroix 2011 Lacroix R, Dignat-George F. Microparticles: new protagonists in pericellular and intravascular proteolysis. Semin Thromb Hemost 2013;39(1):33–39 Brad McEwen 2011 McEwen BJ, Morel-Kopp MC, Chen W, Tofler GH, Ward CM. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. Semin Thromb Hemost 2013;39(1):25–32 Neil A. Goldenberg 2011 Bernard TJ, Armstrong-Wells J, Goldenberg NA. The institution-based prospective inception cohort study: design, implementation, and quality assurance in pediatric thrombosis and stroke research. Semin Thromb Hemost 2013;39(1):10–14 Vivien Chen 2011 Chen VM. factor and Semin Thromb Hemost 2011 mechanisms that platelet Semin Thromb Hemost R, B. New insights into the role of in Semin Thromb Hemost A, Willebrand for function. Semin Thromb Hemost venous thromboembolism in Semin Thromb Hemost and in laboratory diagnosis of von Willebrand disease. Semin Thromb Hemost BJ, Chen and of and international recent experience and outcome from Semin Thromb Hemost for thrombotic and Semin Thromb Hemost. 2014 2014 A, Laboratory diagnosis of acquired hemophilia and Semin Thromb Hemost 2014 risk in the antiphospholipid syndrome. Semin Thromb Hemost 2014 M, M, F. of an on young with Semin Thromb Hemost 2014 as a laboratory during therapy in patients with hemophilia and Semin Thromb Hemost 2014 R, L, von Willebrand factor under for Semin Thromb Hemost 2014 R, A, M. of hemophilia half-life factor and gene therapy. Semin Thromb Hemost 2015 J, M, T, J, in the of platelet syndrome. Semin Thromb Hemost 2015 L, T, B, M. of of therapy. Semin Thromb Hemost 2015 L, M, L, L, J, J, of hemostasis and of in pregnant women with risk of Semin Thromb Hemost 2015 Venous thromboembolism in is it Semin Thromb Hemost 2015 M, or of Semin Thromb Hemost M. 2015 Cannegieter Risk for venous Semin Thromb Hemost These to the Young Investigator award and I to their to These also that Young Investigator Awardees have very high and I the best of to the set by earlier I would as to the current Young Investigator Awardees for their awards, and will also take the opportunity to thank previous Young Investigator Awardees for their these have been well received by of this journal. I to and the of the contributions from the latest group of Young