March 1, 2002Clinical Physiology and Functional Imaging

Effects of in vitro exposure of alcohol on surface receptor expression of human platelets

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Why the study?

Does in vitro exposure to ethanol reduce surface receptor expression on human platelets?

Population

Blood samples from 10 healthy volunteers

Design

Preclinical

Follow-up

30 minutes (incubation)

Authors

MMMarcus E. McKenzieMedStar Washington Hospital Center CBChristopher R. BellPublic Health England EHEric D. HorowitzUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

May suggest antiplatelet mechanism for alcohol; hypothesis-generating and should not change practice pending human studies.

Structured PICO

Does in vitro exposure to ethanol reduce surface receptor expression on human platelets?

Population

Blood samples from 10 healthy volunteers

Intervention

In vitro incubation for 30 min with 25 and 50 mmol l(-1) of phosphate buffered saline diluted grain ethanol

Outcome

Surface expression of platelet receptors (CD 41, CD 42b, CD 62p, CD 51/CD 61, CD 31, CD 107a, CD 107b, CD 63, CD 151) determined by whole blood flow cytometrysurrogate

In vitro exposure to ethanol causes dose-dependent inhibition of major platelet receptors, providing a potential mechanism for the cardiovascular benefits of moderate alcohol consumption.

Cite This Study

McKenzie et al. (2002) studied this question.

synapsesocial.com/papers/6a7544c10b1b00a0ee092d2c https://doi.org/10.1046/j.1365-2281.2002.00411.x

View Full Paper

Ask AI

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Effects of in vitro exposure of alcohol on surface receptor expression of human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of in vitro exposure of alcohol on surface receptor expression of human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider