November 19, 1983BMJOpen Access

Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release.

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Why the study?

Does ethanol inhibit platelet aggregation and thromboxane release without affecting prostacyclin synthesis?

Population

Platelets from healthy volunteers, human endothelial cells, and rat aortic rings

Design

Preclinical

Authors

DMDimitri P. MikhailidisThe Royal Free Hospital JJJamie Y. JeremyUniversity of Bristol MBM.A. BarradasHospital Dr. Nélio Mendonça

Discussion

Member takes

Implication

Does not support ethanol use for antithrombotic effects; leaves open translation of selective thromboxane inhibition to human studies.

Structured PICO

Does ethanol inhibit platelet aggregation and thromboxane release without affecting prostacyclin synthesis?

Population

Platelets from healthy volunteers, human endothelial cells, and rat aortic rings

Intervention

Ethanol (concentrations ranging between 66 and 132 mg/dl in vivo, and various concentrations in vitro)

Outcome

Platelet aggregation, thromboxane A2 release, and prostacyclin (prostaglandin I2) synthesissurrogate

Ethanol selectively inhibits platelet aggregation and thromboxane A2 synthesis without affecting prostacyclin synthesis, providing a potential mechanism for its protective effect against vascular disease.

Cite This Study

Mikhailidis et al. (1983) studied this question.

synapsesocial.com/papers/6a7252e52163a0a01bc60dac https://doi.org/10.1136/bmj.287.6404.1495

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Bookmark

Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider