January 1, 1980Journal of General Virology

Persistent Theiler's Murine Encephalomyelitis Virus Infection in Mice depends on Plaque Size

View Full Paper

Ask AI

Bookmark

Population

Mice inoculated intracerebrally with Theiler's murine encephalomyelitis virus (TMEV)

Design

Preclinical

Authors

HLHoward L. LiptonUniversity of Illinois Chicago

Discussion

Member takes

Implication

Strain-specific TMEV outcomes in mice should not yet inform human care; leaves open determinants of viral persistence in demyelinating disease.

Structured PICO

Population

Mice inoculated intracerebrally with Theiler's murine encephalomyelitis virus (TMEV)

Intervention

Inoculation with large plaque strains of TMEV (GDVII and FA viruses) or small plaque strains (DA, WW, TO4, Yale and BeAn8386 viruses)

Outcome

Type of central nervous system (CNS) infection (acute versus chronic) and associated disease

Small plaque strains of TMEV establish persistent CNS infection and demyelinating disease in mice, unlike large plaque strains which cause acute encephalitis and are cleared.

Cite This Study

Howard L. Lipton (1980) studied this question.

synapsesocial.com/papers/6a754d161078cf7de2b208ea https://doi.org/10.1099/0022-1317-46-1-169

View Full Paper

Ask AI

Bookmark

Implication

Strain-specific TMEV outcomes in mice should not yet inform human care; leaves open determinants of viral persistence in demyelinating disease.

Persistent Theiler's Murine Encephalomyelitis Virus Infection in Mice depends on Plaque Size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Persistent Theiler's Murine Encephalomyelitis Virus Infection in Mice depends on Plaque Size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider