August 15, 2001Journal of VirologyOpen Access

High Numbers of Viral RNA Copies in the Central Nervous System of Mice during Persistent Infection with Theiler's Virus

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Population

Mice susceptible to Theiler's murine encephalomyelitis viruses infection, and cultured macrophages and…

Design

Preclinical

Follow-up

Up to postinfection day 28 and beyond

Authors

MTMark TrottierMichigan State University PKPat KallioNorthwestern University WWWei WangQingdao National Laboratory for Marine Science and Technology

Discussion

Member takes

Implication

High TMEV loads in persistent mouse CNS infection challenge low-level models; leaves open human relevance.

Structured PICO

Population

Mice susceptible to Theiler's murine encephalomyelitis viruses (TMEV) infection, and cultured macrophages and oligodendrocytes

Intervention

Infection with Theiler's murine encephalomyelitis viruses (TMEV), specifically BeAn virus

Outcome

Copy number of TMEV genomes, plus- to minus-strand ratios, and full-length species in the spinal cords of infected mice and infected tissue culture cellssurrogate

TMEV persistence in the mouse central nervous system involves active viral RNA replication with high viral loads, challenging the notion that it persists only at low levels.

Cite This Study

Trottier et al. (2001) studied this question.

synapsesocial.com/papers/6a87ce2e02f504243ce9636f https://doi.org/10.1128/jvi.75.16.7420-7428.2001

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High Numbers of Viral RNA Copies in the Central Nervous System of Mice during Persistent Infection with Theiler's Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High Numbers of Viral RNA Copies in the Central Nervous System of Mice during Persistent Infection with Theiler's Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider