Key result
Lower coronary flow velocity reserve is linked to ~2.2-fold higher death or cardiovascular hospitalization.
Why the study?
Although diabetes mellitus and coronary flow velocity reserve (CFR) predict cardiovascular events, whether Doppler echocardiography-derived CFR predicts cardiovascular outcomes in non-diabetic patients with negative coronary angiograms was unclear.
Cohort (n=91)
Answers are grounded in this paper and cite their sources.
Shows lower coronary flow velocity reserve predicts adverse cardiovascular events in non-diabetic individuals with normal angiograms, indicating microvascular prognostic value.
IntroductionDiabetes mellitus (DM) and coronary flow velocity reserve (CFR) are important predictors of cardiovascular events. The present study was designed to examine whether cardiovascular outcome can be predicted by Doppler echocardiography-derived CFR even in non-diabetic patients with negative coronary angiograms.MethodsThe present study was comprised of 91 non-diabetic patients with normal epicardial coronary arteries. They all had undergone standard transthoracic Doppler echocardiography, coronary angiography and dipyridamole stress transesophageal echocardiography (CFR measurement).ResultsDuring this follow-up period of 90 ± 36 months, 26 patients died or were hospitalized due to cardiovascular reasons. Using ROC analysis, CFR <2.2 had the highest accuracy in predicting event-free survival (sensitivity 62%, specificity 73%, area under the curve 66%, p =0.024). Multivariable regression analysis showed that only lower CFR (hazard ratio (HR) 2.22, p <0.05) was independent predictor of outcome.ConclusionsCFR is an independent predictor of event-free survival in non-diabetic subjects with negative coronary angiograms.
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Nemes et al. (2012) conducted a cohort in Non-diabetic patients with negative coronary angiograms (n=91). Lower coronary flow velocity reserve (CFR <2.2) vs. Higher coronary flow velocity reserve (CFR ≥2.2) was evaluated on Death or hospitalization due to cardiovascular reasons (event-free survival) (HR 2.22, p=<0.05). Lower coronary flow velocity reserve independently predicted death or cardiovascular hospitalization in non-diabetic patients with normal coronary angiograms (HR 2.22, p<0.05).
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