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October 24, 2022Frontiers in PharmacologyOpen Access

Effects of sacubitril-valsartan on heart failure patients with mid-range ejection fractions: A systematic review and meta-analysis

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Why the study?

The effect of sacubitril-valsartan in heart failure patients with mid-range ejection fraction remains unclear.

Does sacubitril-valsartan improve left ventricular function, quality of life, and reduce readmission rates in patients with heart failure with mid-range ejection fractions compared to ACEI or ARB?

Population

1,937 HFmrEF patients across 16 studies

Comparison

Sacubitril-valsartan (ARNI) vs ACEI or ARB

Design

Systematic review and meta-analysis

Authors

JQJianbin QinWWWeijian WangPWPing Wei

Discussion

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Overview

ARNI improves LV function and QoL in HFmrEF; extends ARNI benefits beyond HFrEF with prior limited data.

Structured PICO

Does sacubitril-valsartan improve left ventricular function, quality of life, and reduce readmission rates in patients with heart failure with mid-range ejection fractions compared to ACEI or ARB?

P
Population
16 studies involving 1,937 patients with heart failure with mid-range ejection fractions (HFmrEF)
I
Intervention
Sacubitril-valsartan (ARNI)
C
Comparator
Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB)
O
Outcome
Left ventricular functions, indicators related to HF, quality of life score, 6-Minute Walk Test, total effective rate, mortality, readmission rate, and adverse events

Sacubitril-valsartan may improve left ventricular function, quality of life, and reduce readmission rates in patients with HFmrEF compared to ACEI or ARB.

Limitations

  • Lack of long-term clinical studies with large samples

Cite This Study

Qin et al. (2022) studied this question.

synapsesocial.com/papers/6a7563ee1646b2abe5036b69https://doi.org/10.3389/fphar.2022.982372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of sacubitril valsartan in treating heart failure with midrange ejection fraction after acute myocardial infarction in diabetic patients2022 · 7 citations
  2. 2Sacubitril/Valsartan Improves Autonomic Function and Cardiopulmonary Parameters in Patients with Heart Failure with Reduced Ejection Fraction2020 · 28 citations
  3. 3Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction2019 · 2,428 citations
  4. 4Lower Hospitalization and Healthcare Costs With Sacubitril/Valsartan Versus Angiotensin‐Converting Enzyme Inhibitor or Angiotensin‐Receptor Blocker in a Retrospective Analysis of Patients With Heart Failure2019 · 28 citations
  5. 5A comprehensive review of chronic heart failure pharmacotherapy treatment approaches in African Americans2019 · 15 citations