Population
Streptozotocin (STZ)-induced diabetic rats (Type I model) and obese Zucker rats (Type II model)
Comparison
Acute volume expansion with isotonic saline vs Control rats and diabetic rats treated with…
Design
Review
Authors
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Blunted volume reflex in diabetic models may involve veno-atrial stiffness; leaves open human relevance and insulin effects on volume homeostasis.
Diabetic rats exhibit a blunted volume reflex characterized by reduced natriuresis and diuresis, partly due to increased veno-atrial stiffness, which may contribute to long-term cardiovascular complications like hypertension.
Kaushik M. Patel (1997) studied this question.
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