The interaction between IRAG and InsP3RI plays a central role in NO/cGMP-dependent inhibition of platelet aggregation and in vivo thrombosis.
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IRAG-InsP3RI interaction is required for NO-mediated antithrombotic effects in mice; leaves open its relevance as a drug target in human thrombosis.
Antl et al. (2006) studied this question.
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