Key result
Inositol-1,4,5-trisphosphate receptor-associated protein (IRAG) functions as a crucial signaling pathway component by which nitric oxide and cGMP mediate platelet inhibition.
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Design
Editorial
This commentary highlights the discovery of IRAG's role in NO- and cGMP-mediated platelet inhibition, providing new insights into platelet signaling mechanisms.
[Comment on Antl et al, page 553][1]In this issue of Blood , Antl and colleagues identify inositol-1,4,5-trisphosphate receptor–associated protein (IRAG) as a protein important in the signaling pathway by which nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) mediate platelet inhibition
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Xiaoping Du (2007) studied this question. Inositol-1,4,5-trisphosphate receptor-associated protein (IRAG) functions as a crucial signaling pathway component by which nitric oxide and cGMP mediate platelet inhibition.
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