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May 1, 1973CirculationOpen Access

Hemodynamic Abnormalities in Response to Mild and Intense Upright Exercise following Operative Correction of an Atrial Septal Defect or Tetralogy of Fallot

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Why the study?

Does operative correction of ASD or tetralogy of Fallot restore normal hemodynamic responses to intense upright exercise in asymptomatic patients?

Population

22 asymptomatic patients, including 12 who had atrial septal defects closed and 10 who had total correction…

Comparison

Catheterization studies during mild and intense… vs Normal subjects (reference values).

Design

Cross-sectional

Authors

SEStephen E. EpsteinBroad InstituteGBG. DAVID BEISERWeatherford CollegeRGRobert E. GoldsteinElectrophysiology

Discussion

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Implication

Impaired exercise hemodynamics may persist after ASD or TF repair despite normal rest; hypothesis-generating for exercise testing in surveillance.

Structured PICO

Does operative correction of ASD or tetralogy of Fallot restore normal hemodynamic responses to intense upright exercise in asymptomatic patients?

P
Population
22 asymptomatic patients, including 12 who had atrial septal defects (ASD) closed and 10 who had total correction of tetralogy of Fallot (TF).
I
Intervention
Catheterization studies during mild and intense upright treadmill exercise.
C
Comparator
Normal subjects (reference values).
O
Outcome
Hemodynamic response, including cardiac output, right ventricular (RV) outflow gradients, and RV systolic pressures during exercise.surrogate

Asymptomatic patients with surgically corrected ASD or tetralogy of Fallot may exhibit impaired cardiac output and markedly elevated right ventricular pressures during intense upright exercise despite normal resting hemodynamics.

Cite This Study

Epstein et al. (1973) studied this question.

synapsesocial.com/papers/6a7574dd99129e9915f58e1fhttps://doi.org/10.1161/01.cir.47.5.1065
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of Cardiac Function1969 · 172 citations
  2. 2Hemodynamic Studies Two Weeks to Six Years after Repair of Tetralogy of Fallot1964 · 25 citations
  3. 3Results of Repair of Tetralogy of Fallot1969 · 62 citations
  4. 4An Evaluation of Total Correction of Tetralogy of Fallot1963 · 23 citations