Key result
Total correction of tetralogy of Fallot in adult life yielded good clinical condition in 78% of patients at 6.3 years, with exercise capacity maintained despite right ventricular impairment.
Why the study?
Does total correction of tetralogy of Fallot in adults result in good clinical condition and preserved exercise capacity?
Observational (n=32)
Does total correction of tetralogy of Fallot in adults result in good clinical condition and preserved exercise capacity?
Answers are grounded in this paper and cite their sources.
Total correction of tetralogy of Fallot in adults yields good clinical results, and residual right ventricular impairment does not significantly reduce exercise capacity.
Thirty-two patients who had undergone correction of Fallot's tetralogy in adult life were examined on average 6.3 years postoperatively, at mean age 25.8 years. Palliative shunt operation had been performed in childhood in 28 cases. The clinical condition was good in 25 patients (78%). 13 of whom had mean gradient between right ventricle and pulmonary artery 16.0 +/- 4.2 mmHg and systolic right ventricular pressure 39.0 +/- 10.0 mmHg, while 12 had right ventricular pressure 62.6 +/- 16.3 mmHg. In these groups the maximum exercise capacity was, respectively, 136.7 +/- 36.1 and 106.1 +/- 30.8 W/min. Three other patients were in satisfactory, and four in poor clinical condition, with right ventricular systolic pressure, respectively, 74.3 +/- 10.9 and 91.5 +/- 60.0 mmHg. The gradient from right ventricle to pulmonary artery averaged 58.5 +/- 10.4 mmHg in the latter group but, despite the obstructed pulmonary outflow tract, the exercise capacity (116.7 +/- 28.9 W/min) was similar to that in the groups with better clinical results. It is concluded that in most patients with palliative surgery in childhood, tetralogy of Fallot can be successfully corrected in adult life. The causes of right ventricular impairment do not significantly reduce the exercise capacity.
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Nieminen et al. (1987) conducted an observational in Tetralogy of Fallot (n=32). Total correction of tetralogy of Fallot in adult life was evaluated on Clinical condition, right heart haemodynamics, and exercise capacity. Total correction of tetralogy of Fallot in adult life yielded good clinical condition in 78% of patients at 6.3 years, with exercise capacity maintained despite right ventricular impairment.
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