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December 1, 1977AJP Heart and Circulatory Physiology

End-systolic force-length relationship of nonexcised canine papillary muscle

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Population

Blood-perfused papillary muscles remaining in the canine right ventricle (N = 31)

Comparison

Different modes of contraction at different… vs Comparison between isometric, isotonic, and…

Design

Preclinical

Authors

HSHiroyuki SugaShinshu UniversityYSY. SaekiKSK SagawaGeneral Cardiology

Discussion

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Implication

Does not inform clinical management; leaves open translation of shortening deactivation to intact human ventricles.

Structured PICO

P
Population
Blood-perfused papillary muscles remaining in the canine right ventricle (N = 31)
I
Intervention
Different modes of contraction (isometric, isotonic, auxotonic) at different diastolic lengths
C
Comparator
Comparison between isometric, isotonic, and auxotonic contraction modes
O
Outcome
End-systolic force-length (F-L) relationshipssurrogate

In canine papillary muscles, isotonic force is lower than isometric force at identical end-systolic lengths, likely due to shortening deactivation and viscous properties.

Cite This Study

Suga et al. (1977) studied this question.

synapsesocial.com/papers/6a7579ce0199417375e71900https://doi.org/10.1152/ajpheart.1977.233.6.h711
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A force-length-time relationship describes the mechanics of canine left ventricular wall segments during auxotonic contractions.1981 · 12 citations
  2. 2Cardiac muscle mechanics and ventricular performance: force and time parameters1964 · 112 citations
  3. 3Effects of inotropic interventions on end systolic length-force curve of cat ventricular muscle1987 · 5 citations
  4. 4Maximum rate of tension fall during isometric relaxation at end-systolic fiber length in canine papillary muscle.1977 · 18 citations
  5. 5Diastolic stress-strain relation of nonexcised blood-perfused canine papillary muscle1978 · 29 citations