Key result
Coronary perfusion pressure positively correlates with diastolic stiffness in canine papillary muscles.
Why the study?
The diastolic stress-strain relationship of nonexcised blood-perfused canine papillary muscle and its stiffness characteristics under varying coronary perfusion pressures were not fully characterized.
Population
10 coronary-perfused twitching papillary muscles of the canine right ventricle
Comparison
Different coronary perfusion pressures (75-125 mmHg)
Design
Experimental study of muscle mechanics with slow stretch at constant rate
Authors
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Supports perfusion-dependent diastolic stiffness in canine muscle; leaves open translation to human myocardium.
The diastolic stress-strain relationship of blood-perfused canine papillary muscle follows a single exponential curve, with stiffness constants comparable to those assessed indirectly in vivo.
Kitabatake et al. (1978) studied this question. Coronary perfusion pressure was evaluated on Diastolic stress-strain relationship (stiffness constant b). Coronary perfusion pressure (75-125 mmHg) positively correlated with the stiffness constant b (mean 18.0 ± 3.2) of the diastolic stress-strain relationship in canine papillary muscles.
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