What does this research mean for the field?

In children, the left ventricular volume elastic constant is exponentially related to heart size while the wall stiffness constant is independent of it, and left ventricular stiffness is significantly increased following surgical repair of Tetralogy of Fallot but remains normal after atrial septal defect repair. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to analyze the diastolic pressure-volume and stress-strain relationships specifically during mid-diastole in children.

January 1, 1985Japanese Circulation JournalOpen Access

Left ventricular diastolic pressure-volume and stress-strain relationship in children.

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Population

42 children, comprising a control group and a postoperative congenital heart disease group.

Comparison

Analysis of mid-diastolic pressure-volume and… vs Control group vs postoperative congenital heart…

Design

Cross-sectional

Authors

KYKaoru YoshiiFukuoka Children's Hospital and Medical Center for Infectious Diseases HIH IwaoThe University of Osaka SFShoshi FukudaUniversity of Yamanashi

Discussion

Member takes

Implication

May reflect increased diastolic stiffness after tetralogy repair; leaves open prognostic value and need for validation.

Key Points

This research aims to analyze the diastolic pressure-volume and stress-strain relationships specifically during mid-diastole in children.
Analyzed diastolic pressure-volume (P-V) and stress-strain (sigma-epsilon) relationships in two groups of patients.
Fitted data to exponential curves during mid-diastole.
Assessed 2 normal and 25 patients with post mucocutaneous lymph node syndrome, as well as patients with congenital heart disease.
The elastic constant (a) was exponentially related to heart size (a = 0.30e-0.037EDV + 0.045, r = 0.94, p < 0.01).
Wall stiffness constant (k) did not relate to heart size.
Post-surgical repair showed normal left ventricular stiffness in atrial septal defect but increased stiffness in tetralogy of Fallot patients.

Structured PICO

Population

42 children, comprising a control group (n=29: 2 normal hearts, 2 mild pulmonary stenosis, 25 post mucocutaneous lymph node syndrome) and a postoperative congenital heart disease group (n=13: 8 atrial septal defect, 5 tetralogy of Fallot).

Intervention

Analysis of mid-diastolic pressure-volume (P-V) and stress-strain (sigma-epsilon) relationships

Comparator

Control group vs postoperative congenital heart disease (ASD and ToF)

Outcome

Left ventricular volume elastic constant (a) and wall stiffness constant (k)surrogate

Cite This Study

Yoshii et al. (1985) studied this question.

synapsesocial.com/papers/6a1d8a4aa44061a0895dcc99 https://doi.org/10.1253/jcj.49.385

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Left ventricular diastolic pressure-volume and stress-strain relationship in children.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Left ventricular diastolic pressure-volume and stress-strain relationship in children.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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